[Objective]To present the surgical technique and preliminary clinical results of unilateral biportal endoscopy(UBE)with keyhole technique for paracentral cervical disc herniation.[Methods]A patient with paracentral cervical disc herniation underwent the above treatment.The positions of the surgical portals were determined according to the preoperative images,then the working channel tube was placed onto the upper and lower sides of the lower margin of the right C5 lamina,while the endoscope was placed in the lower portal.As surgical instruments were used in the working channel,the marginal lamina was ground thin,part of the soft tissue and the yellow ligament were removed until the responsible nerve root was fully exposed.After the adhesive tissue was removed,the protruded disc was resected by using nucleus pulposus forceps.[Results]The patient was operated on successfully,had symptoms significantly relieved postoperatively,and could get out of bed the next day.Follow-up period lasted for 1 year,the VAS score significantly decreased from neck and shoulder score of 5 and upper limb of 7 preoperatively to both of 2 at the latest follow-up.The NDI score significantly declined from 26.7%before sur-gery to 6%at the last follow-up.No long-term complications and recurrent symptoms were found.[Conclusion]Keyhole technique under UBE does significantly improve the clinical symptoms of patients with paracentral cervical disc herniation while achieving minimally inva-sive purpose.