[Objective]To evaluate the reliability and effectiveness of combined high tibial osteotomy(HTO)and distal femoral osteoto-my(DFO)in the correction of complex knee varus in adolescents.[Methods]From July 2015 to June 2022,10 patients(12 knees)under-went combined DFO and HTO osteotomy.The clinical and imaging documents were evaluated.[Results]All the patients had operation per-formed successfully without complications,such as vascular and nerve injury during the operation.All the 10 patients were followed up with an average of(21.9±10.3)months,with walking time of(36.9±18.2)days.Compared with those preoperatively,the HSS score[(86.6±5.1),(97.2±1.2),P<0.001]and Lysholm score[(77.5±15.3),(95.7±2.7),P<0.001]significantly increased,whereas VAS scores[(4.2±1.2),(0.7±0.3),P<0.001]significantly decreased at the last follow-up.As for imaging,the proximal medial tibial angle(MPTA)[(72.3±6.6)°,(85.2±1.9)°,P<0.001],mechanical lateral distal femoral angle(mLDFA)[(78.2±5.3)°,(87.4±0.9)°,P<0.001],and femorotibial angle(FTA)[(182.8±4.4)°,(176.6±2.1)°,P<0.001]significantly improved,additionally,the leg length discrepancy(LLD)[(24.6±6.8)mm,(11.9±4.3)mm,P<0.001],and the mechanical axis deviation[(30.9±11.3)mm,(10.4±3.8)mm,P<0.001]significantly declined.[Conclusion]Com-bined DFO and HTO osteotomy do effectively correct the varus deformity of the knee,and increase the length of the affected limb,achieve satisfactory short-term consequence.