[Objective]Mendelian randomization(MR)method was used to investigate the causal relationship between overweight and hip osteoarthritis,in order to provide theoretical basis for clinical prevention and treatment.[Methods]Using publicly available data from the Genome-wide association study(GWAS),overweight as an exposure factor and hip osteoarthritis as an outcome factor,instrumental vari-able(IV)related to overweight was extracted.The MR method based on inverse-variance weighted(IVW)method was the main research method.In additon,the MR-Egger method,weighted median(WME)method and weighted mode(WM)method and simple mode method(SM)was used to verify the results.Furthermore,the results were tested for heterogeneity,sensitivity and pleiotropy.[Results]IVW results showed that overweight was positively correlated with hip osteoarthritis(OR=1.720,95％CI 1.320～2.250;P=6.23942E-05,＜0.01).The re-sult of MR-Egger analysis suggested that there was no pleiotropy in this study(P=0.503).The results of Cochran's Q test(P=0.540)suggest-ed that there is no heterogeneity in the results of this study.The single nucleotide polymorphisms(SNPS)used for MR Analysis were removed successively,which indicated that a single SNP could not significantly affect the overall effectiveness,indicating that results of this study were stable and reliable.[Conclusion]There is a causal relationship between overweight and hip osteoarthritis.
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