[Objective]To investigate the effect of posterior tibial slope of the tibial component on fixed bearing unicompartmental knee arthroplasty(FB-UKA).[Methods]A retrospective study was performed on 59 patients who received FB-UKA for medial knee osteoarthritis in our hospital from August 2019 to June 2022.Based on the postoperative PTS measured on radiographs,the patients were classified into the<6° group,and the 6°~9° group.The clinical and imaging consequences were evaluated and compared between them.[Results]All the 59 patients had FB-UKA performed successfully with no serious complications occurred during perioperative period,and followed up for(12.6±4.9)months in mean.Compared with those preoperatively,the ROM,KSS clinical score and KSS functional score significantly in-creased postoperatively in both groups(P<0.05).The 6°~9° group proved significantly superior to the>6° group in terms of ROM[(119.3±9.1)° vs(113.4±10.4)°,P<0.001],KSS clinical score[(95.3±7.8)vs(91.3±6.2),P=0.035],KSS functional score[(92.6±5.9)vs(88.9±7.6),P=0.041]6 months postoperatively.As for imaging,the mFTA significantly increased in both groups 1 month after surgery compared with that preoperatively(P<0.05).There were no significant differences in postoperative mFTA,FC-VA,TC-VA between the two group(P>0.05),whereas the<6° group had significantly less PTS than the 6°~9° group postoperatively[(5.2±0.3)° vs(7.9±0.4)°,P<0.001].[Conclusion]The PTS in 6° to 9° might be benefit to improve the range of motion and knee function in FB-UK.