[Objective]To investigate the clinical outcomes of low-dose naloxone in thoracolumbar interfascial plane(TLIP)block dur-ing perioperative period of transforaminal lumbar interbody fusion(TLIP).[Methods]A total of 82 patients who were undergoing TLIF under general anesthesia for lumbar degenerative diseases from May 2020 to May 2023 were included in this study.According to the preoperative doctor-patient communication,40 patients received conventional TLIP block(conventional group),while other 42 cases received low-dose naloxone in TLIP block(naloxone group).The perioperative clinical and analgesic data of the two groups were compared.[Results]There were no significant differences in operation time,intraoperative blood loss,incidence of adverse reactions between the two groups(P＞0.05).The VAS scores in both groups increased firstly and then decreased in the period from 2 hours to 48 hours after surgery.However,the nalox-one group was marked significantly lower VAS scores 6,24 and 48 hours than the conventional group(P＜0.05).In addition,the naloxone group proved significantly superior to the conventional group in terms of the time of the first remedial analgesia use[(10.5±1.8)hours vs(6.4±1.6)hours,P＜0.001],the number of PCIA press[(6.4±0.9)times vs(8.1±1.5)times,P＜0.001],sufentanil doses[(72.6±14.6)μg vs(84.5±17.6)μg,P=0.001],and the number of additional analgesia[(1.2±0.4)times vs(1.8±0.2)times,P＜0.001].[Conclusion]TLIP block with low-dose naloxone can effectively relieve early pain symptoms,and reduce the use and frequency of postoperative analgesics during periop-erative period of TLIF.
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