[Objective]To evaluate the safety and early clinical efficacy of 3D printed semi-pelvis reconstruction for defect secondary to tumor resection.[Methods]A retrospective study was done on 12 patients who received semi-pelvis reconstruction with 3D printed pros-theses for pelvic tumor in our department from January 2022 to April 2023.The documents regarding to perioperative conditions and short-term follow-up results were evaluated.[Results]All the 12 patients were successfully operated,with an average operation time of(339.3±97.1)min,intraoperative blood loss of(956.3±708.8)ml,the intraoperative suspended red blood cell infusion of(4.5±3.0)units,and intraop-erative plasma infusion of(412.5±359.4)ml.All of them were followed up for(7.2±4.0)months on an average,1 patient died 7 months after surgery due to tumor progression,and 1 patient suffered dislocation 1 year after surgery and underwent surgical reduction.Compared with those preoperatively,pain VAS score significantly decreased at the last follow-up[(3.3±0.5),(2.0±0.7),P=0.014],whereas the Harris hip score[(46.7±5.4),(64.8±7.3),P=0.003],the MSTS score[(11.0±4.8),(16.3±2.9),P<0.001]significantly increased.[Conclusion]The semi-pelvis reconstruction with 3D printed prostheses does effectively reduce the pain,and improve the function postoperatively,which is a safe and effective reconstruction method.