前交叉韧带断裂关节腔内环境改变的研究进展
Research progress on the intraarticular environment variation secondary to anterior cruciate ligament tear
周塏 1杜秀藩 1王广积1
作者信息
- 1. 海南医学院附属海南省人民医院运动医学科,海南海口 570311
- 折叠
摘要
前交叉韧带(anterior cruciate ligament,ACL)断裂多发于运动的人群,特别是年轻人,该韧带断裂后由于关节腔内环境以及关节力学的改变,导致膝关节疼痛、不稳定以及活动功能障碍等症状,给患者带来长期的负面影响.有许多研究表明,ACL断裂后可引起滑膜炎症、软骨细胞损伤以及软骨基质的降解,最后导致创伤后骨关节炎(posttraumatic osteoarthritis,PTOA)形成,其中引起关节腔内这些变化的原因可能与ACL断裂后关节腔内环境改变有着密切的关系.本文主要从ACL断裂后关节腔内环境的改变出发,分析术前术后关节腔内环境的改变对患者预后的影响,为ACL断裂后形成PTOA提供一个可靠的科学依据.
Abstract
Anterior cruciate ligament(ACL)tear is more common in people who exercise,especially in young people.Due to the change of intraarticular environment and joint mechanics,the rupture of this ligament can lead to symptoms such as knee pain,instability and mobility dysfunction,which will bring long-term negative effects to patients.It is worth noting that many studies have shown that ACL rupture can cause synovial inflammation,chondrocyte injury and cartilage matrix degradation,and finally lead to posttraumatic osteoarthri-tis(PTOA).The causes of these changes in the articular cavity may be closely related to the changes in the articular cavity environment af-ter ACL tear.Therefore,based on the changes in the intraarticular environment after ACL rupture,this paper mainly analyzes the influence of the changes in the intraarticular environment before and after surgery on the prognosis of patients,and provides a reliable scientific basis for the predicating PTOA after ACL rupture.
关键词
前交叉韧带断裂/关节腔内环境/创伤后骨关节炎Key words
anterior cruciate ligament rupture/intraarticular environment/posttraumatic osteoarthritis引用本文复制引用
基金项目
海南医学院科研培育基金项目(HYPY2020014)
国家自然科学基金培育530工程面上项目(2021MSXM10)
出版年
2024
NETL
NSTL
万方数据