[Objective]To investigate the factors related to pigmentation of cutaneous neurotrophic vascular flap for repair of soft tissue defect.[Methods]A retrospective study was conducted on 185 patients who received cutaneous neurotrophic vascular flap in emergency for repair of soft tissue defect in our hospital from January 2013 to February 2022.They were divided into pigmentation group and non-pigmen-tation group according to whether pigmentation occurred 3 months after the skin flap operation.Univariate comparison and multivariate logis-tic regression were used to analyze the factors related to the pigmentation.[Results]Among the 185 patients,36 patients were confirmed as pigmented,accounting for 19.5％;while the raining 149 cases were non-pigmented,accounting for 80.5％.As result of univariate compari-son,the pigmented group proved significantly higher ratio than the non-pigmented group in terms of smoking[Y/N,(24/12)vs(67/82),P=0.019],diabetes[Y/N,(15/21)vs(25/124),P=0.010],hypertension[Y/N,(18/18)vs(28/121),P＜0.001],early vascular crisis[Y/N,(14/22)vs(5/144),P＜0.001],and the former had significantly greater time interval between injury and operation[(8.5±2.4)h vs(7.1±3.1)h,P=0.019].However,the pigmented group was significantly lower than the non-pigmented group in ratios of vascular anastomosis[Y/N,(4/32)vs(75/74),P＜0.001]and early flap survival[Y/N,(24/12)vs(145/4),P＜0.001].Regarding to logistic regression analysis,the early vascular crisis(OR=20.228,P=0.042),hypertension(OR=7.727,P＜0.001),smoking(OR=4.129,P=0.010),diabetes(OR=4.121,P=0.012)were indepen-dent risk factors for skin flap pigmentation,while vascular anastomosis(OR=0.080,P=0.001)was of protective factors.[Conclusion]Skin flap pigmentation is more likely to occur in patients with smoking,hypertension,diabetes and early postoperative vascular crisis,while vascu-lar anastomosis can reduce the occurrence of pigmentation.
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