脊髓损伤神经调控重建脊髓中继环路
Neuromodulation to reconstructs the spinal relay neural circuit secondary to spinal cord injury
李艺 1李文媛 1王淑影 1王莹1
作者信息
- 1. 牡丹江医学院解剖教研室,黑龙江牡丹江 157011
- 折叠
摘要
脊髓损伤(spina cord injury,SCI)破坏大脑和脊髓中神经环路间的信号传递,造成永久性运动、感觉丧失及自主神经功能障碍等.位于脊髓损伤灶上端和下端大多数神经环路在解剖学上保持完整,上述环路可通过脊髓中继神经环路传递下行运动信号.因此,重建中继性神经环路是最具前途的治疗策略之一.其中神经调控技术能够利用残余大脑、脑干和脊髓神经元重建脊髓中继神经环路,改善SCI后神经功能障碍.为了解神经调控技术重建SCI后中继神经环路的最新进展,本文针对SCI后大脑皮质、脑干和脊髓的中继神经环路重建进行综述,进一步讨论SCI后相关神经环路神经调控的潜在机制及其意义.
Abstract
Spina cord injury(SCI)disrupts the signal transmission of the central nerve circuit of the spinal cord,resulting in permanent movement,sensory loss and autonomic dysfunction.However,most of the neural circuits located at the upper and lower lesion remain ana-tomically intact,and these circuits can transmit descending motor signals through spinal cord relay circuits.Therefore,reconstruction of the relayed neural circuit has become one of the most promising therapeutic strategies.Among them,neuroregulatory technique can reconstruct the spinal cord trunk neural circuit by using the residual brain,brainstem and spinal cord neurons,and improve the neurological dysfunction after SCI.In order to understand the latest progress of neuroregulatory techniques in the reconstruction of relayed neural circuits after SCI,this paper reviews the reconstruction of relayed neural circuits in the cerebral cortex,brainstem and spinal cord after SCI,and further dis-cusses the potential mechanism and significance of the neural regulation of relevant neural circuits after SCI.
关键词
神经调控/脊髓损伤/神经环路/功能整合/中继通路Key words
neuromodulation/spinal cord injury/neural circuit/functional integration/relay pathway引用本文复制引用
基金项目
国家自然科学基金项目(82371385)
黑龙江省自然科学基金项目(JQ2021H004)
黑龙江省属高校基本科研业务费项目(2021-KYYWF-0469)
牡丹江医学院科学基金火炬计划项目(2022-MYHJ-012)
牡丹江医学院博士科研启动基金项目(2021-MYBSKY-039)
出版年
2024
NETL
NSTL
万方数据