首页|骨质疏松性髋部骨折是否合并支气管扩张比较

骨质疏松性髋部骨折是否合并支气管扩张比较

Comparison of clinical outcomes of osteoporotic hip fractures with or without bronchiectasis

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[目的]研究骨质疏松性髋部骨折合并支气管扩张(bronchiectasis,BE)患者的特点,以便更好地进行围手术期的评估和管理.[方法]回顾性分析本院2020年1月-2022年10月骨质疏松性髋部骨折住院并手术患者的临床资料,筛选出支气管扩张患者48例(BE组),无支气管扩张患者(non-BE组)48例.采用单项因素比较,两两相关分析和二分逻辑回归分析BE 的影响因素.[结果]与 non-BE 患者相比,BE 患者的骨密度(bone mineral density,BMD)T 值[(-2.5±0.4)vs(-2.2±0.6),P=0.003]和维生素D水平[(14.9±2.3)ng/ml vs(18.5±2.4)ng/ml,P<0.001]显著降低,而术后急性肺部感染发生率显著升高[例(%),20(41.7)vs5(10.4),P<0.001],但两组术后1年死亡率的差异无统计学意义(P>0.05).BE组患者的分层比较:发生急性肺部感染组患者的维生素D水平较低、术后1年死亡比例高、支气管扩张严重程度指数(bronchiectasis severity index,BSI)分级重(P<0.05);术后1年死亡组的维生素D水平低、卧床时间长、BSI分级重、术后急性肺部感染发生率高(P<0.05).两两相关分析表明,BSI分级与BMD及维生素D水平呈显著负相关(P<0.05),与卧床时间呈显著正相关(P<0.05).术后1年内是否死亡的逻辑回归表明,急性肺部感染(OR=9.16,P=0.023)和术中出血量(OR=1.11,P=0.037)是术后1年死亡的独立危险因素.维生素D水平高不是术后1年死亡的独立危险因素(OR=0.720,P=0.181).[结论]骨质疏松性髋部骨折并支气管扩张患者BMD和维生素D水平明显降低,术后更易发生急性肺部感染,BMD和维生素D水平降低与支气管扩张严重程度相关.术后急性肺部感染、术中出血量是术后1年死亡的独立危险因素.
[Objective]To study the characteristics of osteoporotic hip fractures complicated with bronchiectasis(BE)for better periop-erative evaluation and management.[Methods]From January 2020 to October 2022,48 patients with bronchiectasis(the BE group)and 48 patients without BE(the non-BE group)were selected from those who underwent surgical treatment for osteoporotic hip fractures in our hos-pital.The impacts of BE were analyzed by univariate comparison,pairwise correlation analysis and binary logistic regression analysis.[Re-sults]The BE patients had significantly lower bone mineral density(BMD)T value[(-2.5±0.4)vs(-2.2±0.6),P=0.003]and vitamin D lev-els[(14.9±2.3)ng/ml vs(18.5±2.4)ng/ml,P<0.001]than the non-BE group,whereas the former had significantly higher incidence of postop-erative acute pulmonary infection than the latter[cases(%),20(41.7)vs 5(10.4),P<0.001],despite of no significant difference in mortality in a year postoperatively between them(P>0.05).In term of stratified comparison in the BE patients:the patients with acute pulmonary in-fection had lower vitamin D levels,higher mortality in a year after surgery,and more severe bronchiectasis severity index(BSI)than those without acute pulmonary infection(P<0.05).In addition,the death group had lower vitamin D level,longer bed rest time,more severe BSI grade and higher incidence of postoperative acute pulmonary infection than the alive group(P<0.05).As for pairwise correlation,the BSI grade was negatively correlated with BMD and vitamin D levels,while positively correlated with bed rest duration(P<0.05).As results of lo-gistic regression,the acute pulmonary infection(OR=9.16,P<0.05)and intraoperative blood loss(OR=1.11,P<0.05)were independent risk factors for death in one year after surgery,while high vitamin D levels may be a protective factor for death(OR=0.720,P>0.05).[Conclu-sion]The patients with osteoporotic hip fracture complicated with BE usually have reduced bone mineral density and vitamin D levels,and are prone to acute pulmonary infection after surgery.The decrease of BMD and vitamin D levels are related to the BE severity.Postopera-tive acute pulmonary infection and intraoperative blood loss were independent risk factors for death in 1 year after surgery.

osteoporosiship fracturesbronchiectasisprognosisinfluencing factors

邱立洁、高程鹏、姜晓雪、孙雪玲、刘德秋、张永强

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山东第二医科大学第一附属医院(潍坊市人民医院)呼吸与危重症医学科,山东潍坊 261000

山东第二医科大学第一附属医院(潍坊市人民医院)创伤骨科,山东潍坊 261000

骨质疏松 髋部骨折 支气管扩张 预后 影响因素

潍坊市卫健委科研项目

WFWSJK-2022-133

2024

中国矫形外科杂志
中国残疾人康复协会 中国人民解放军第八十八医院

中国矫形外科杂志

CSTPCD北大核心
影响因子:1.521
ISSN:1005-8478
年,卷(期):2024.32(14)
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