[Objective]To search the factors affecting fracture-related infection(FRI)after fixation of lower extremity fracture.[Meth-ods]A total of 5 982 patients received surgical treatment for lower extremity fractures in Tangshan Second Hospital from January 2018 to January 2022.Of them,83 patients proved FRI were fall into the FRI group,while other 166 patients without FRI were selected as the non-FRI group based on fracture site,fracture operation,gender and age matching.The risk factors related to FRI after lower limb fracture fixa-tion were analyzed by univariate comparison and binary multifactor logistic regression.[Results]Of 5 982 patients who underwent surgical treatment for lower extremity fractures,83 patients had FRI after operation,with the incidence of 1.4％.The FRI group proved significantly greater than the non-FRI group in terms of smoking[y/n,(36/47)vs(35/131),P＜0.001],diabetes[y/n,(25/58)vs(21/145),P＜0.001],open damage[yes/no,(27/56)vs(18/148),P＜0.001],ASA classification[Ⅰ/Ⅱ/Ⅲ,(31/17/35)vs(29/41/96),P=0.002],BMI[(27.2±3.6)kg/m2 vs(25.5±2.7)kg/m2,P＜0.001],operation time[(180.0±48.0)min vs(138.5±44.6)min,P＜0.001],intraoperative blood loss[(351.6±101.5)ml vs(298.5±128.3)ml,P＜0.001],whereas the former had significantly less preoperative ALB than the latter[(34.4±2.4)g/L vs(37.2±4.0)g/L,P＜0.001].As consequences of multi-factor logistic regression,the open injury(OR=3.658,P=0.005),smoking history(OR=2.436,P=0.014),poor ASA grade(OR=1.754,P=0.028),high BMI(OR=1.190,P=0.003),and long operation time(OR=1.021,P＜0.001)were the indepen-dent risk factors for FRI after lower limb fracture fixation,while the high preoperative ALB(OR=0.803,P＜0.001)was a protective factor.[Conclusion]The patients with smoking history,prolonged operation time,high BMI,severe ASA grade,and open injury have higher risk of lower limb FRI,and corresponding clinical measures should be taken to prevent it.
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