[Objective]To investigate the clinical outcomes of interlocking intramedullary nail combined with tibiofibular screw for fix-ation of distal fibular fracture complicated with inferior syndesmosis injury.[Methods]A retrospective study was conducted on 29 patients who had distal fibular fracture fixed with interlocking intramedullary nail,and tibiofibular syndesmosis fixed by tricortical screw in our hos-pital from January 2019 to February 2022.The clinical and imaging data were evaluated.[Results]All patients were operated successfully with operation time of(51.8±10.3)min,the intraoperative blood loss of(68.3±14.3)ml,the total incision length of(42.5±3.6)mm,and fol-lowed up for(13.7±2.4)months.The VAS score,AOFAS score and ankle ROM were significantly improved over time(P<0.05).In terms of imaging,compared with those preoperatively,the inferior tibiofibular overlap(TFO)[(2.1±0.7)mm,(8.1±1.3)mm,(8.0±1.1)mm,P<0.001]and talocrural angle(TCA)[(73.9±4.2),(83.1±3.0),(82.4±2.9),P<0.001]increased significantly 6 months after surgery and at the latest fol-low-up,while the tibiofibular clear space(TFCS)decreased significantly[(8.3±1.3)mm,(4.3±0.5)mm,(4.4±0.5)mm,P<0.001].[Conclu-sion]The interlocking intramedullary nail combined with tibiofibular screw does effectively treat distal fibular fracture complicated with in-ferior tibiofibular syndesmosis injury,with advantages of small incision,less bleeding,anti-rotation and reliable fixation of the syndesmosis.