Gorham-Stout病合并脊柱畸形:1例报告和综述
Gorham-Stout disease with spinal deformity:a case report and literature review
张垚 1宋继鹏 1姚思远 1丁立祥1
作者信息
- 1. 首都医科大学附属北京世纪坛医院,北京 100038
- 折叠
摘要
Gorham-Stout病(Gorham-Stout disease,GSD)是特发性骨溶解症的一种,罕发脊柱受累.GSD的发病机制尚不明确,病程多变,诊断和治疗极具挑战性.当骨溶解引发病理性骨折、畸形时,及时进行手术干预可促进新骨形成,控制骨溶解进展.在本报道中,患者以多个腰椎骨溶解合并畸形为特征,接受了药物治疗以及3次手术干预.在末次手术时,病椎邻近软组织发生了浸润性破坏,严重的出血迫使笔者简化了手术方案.经过26个月的随访,患者的骨溶解得到了控制,脊柱畸形未再进展.多椎骨受累的GSD病具有很高的进展潜能,即便畸形较轻,一期长节段固定融合仍是较为稳妥的手术方式.此外,本文对相关文献进行综述.
Abstract
Gorham-Stout disease(GSD)is a sort of idiopathic osteolysis disease,in which with involvement of spine is rare.The diag-nose and treatment of GSD are particular challenging as the pathological mechanism is currently unclear and the course of disease is vari-able.When the osteolysis has resulted in pathological fracture or deformity,early surgical intervention is able to facilitate new bone forma-tion and arrest the progression of osteolysis.In this paper,a patient who was characterized by multiple osteolysis of lumbar spine with defor-mity was treated by medication and three-time surgical interventions.During the last surgery,the soft tissues adjacent to the damaged verte-brae were diffusively destructed.The massive hemorrhage had forced us to simplify the surgical procedure.With a 26-month follow-up,we observed that the osteolysis and the deformity were halted.The progression potential is high in the GSD with multiple vertebrae involved.Even the deformity is mild,one-stage long-segmental fiixation and fusion remains a reliable choice.
关键词
Gorham-Stout病/特发性骨溶解/淋巴管瘤病/脊柱畸形/手术干预Key words
Gorham-Stout disease/idiopathic osteolysis/lymphangiomatosis/spinal deformity/surgical intervention引用本文复制引用
出版年
2024
NETL
NSTL
万方数据