Gorham-Stout disease(GSD)is a sort of idiopathic osteolysis disease,in which with involvement of spine is rare.The diag-nose and treatment of GSD are particular challenging as the pathological mechanism is currently unclear and the course of disease is vari-able.When the osteolysis has resulted in pathological fracture or deformity,early surgical intervention is able to facilitate new bone forma-tion and arrest the progression of osteolysis.In this paper,a patient who was characterized by multiple osteolysis of lumbar spine with defor-mity was treated by medication and three-time surgical interventions.During the last surgery,the soft tissues adjacent to the damaged verte-brae were diffusively destructed.The massive hemorrhage had forced us to simplify the surgical procedure.With a 26-month follow-up,we observed that the osteolysis and the deformity were halted.The progression potential is high in the GSD with multiple vertebrae involved.Even the deformity is mild,one-stage long-segmental fiixation and fusion remains a reliable choice.
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