[Objective]To evaluate the clinical efficacy of separation decompression combined with microwave ablation and vertebro-plasty in the treatment of spinal metastases complicated with nerve compression.[Methods]A retrospective study was conducted on 26 pa-tients who underwent separation decompression combined with microwave ablation and vertebroplasty for spinal metastasis complicated with nerve compression from March 2018 to June 2023.The operation time,intraoperative blood loss,microwave ablation time and bone cement injection amount were recorded.ASIA neurological scale,visual analogue scale(VAS)for pain,Oswestry disability index(ODI)and Karnof-sky performance scale(KPS)were used to evaluate clinical outcomes.In addition,CT and MRI were periodically reviewed to observe the tu-mor infiltration in the bone and soft tissue around the bone cement in the operative area,and to evaluate the local control of the tumor.[Re-sults]All the 26 patients had operation performed successfully with operation time of(127.3±51.4)min,the intraoperative blood loss of(358.5±241.7)ml,the microwave ablation time of(12.2±3.7)min,and the injected bone cement of(4.7±2.1)ml.However,there was no spi-nal cord and nerve root injury in anyone of them,with good position of implants and bone cement.The VAS for pain[(8.2±1.4),(3.4±1.1),(2.6±0.6),(2.0±0.5),P＜0.001],ODI[(83.7±11.3),(35.2±7.6),(14.2±2.4),(13.2±2.3),P＜0.001]and KPS scores[(41.7±16.4),(68.4±16.3),(76.4±15.6),(80.2±11.6),P＜0.001]significantly improved as time went preoperatively,1 month,3 months and 6 months postoperatively.Fur-thermore,the ASIA neurological scale significantly improved over time(P＜0.05).At 6 months postoperatively,all patients had tumor well controlled in the operative area without tumor recurrence,except 3 patients who died due to the primary disease.[Conclusion]The separa-tion decompression combined with microwave ablation and verteboplasty do effectively relieve pain,relieve nerve compression and restore spinal stability,control local tumors and improve patients'quality of life.
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