[Objective]To compare clinical outcomes of unicompartmental knee arthroplasty(UKA)versus total knee arthroplasty(TKA)for medial compartment knee osteoarthritis(MC-KOA)in the elderly.[Methods]A retrospective analysis was conducted on 109 el-derly patients who received knee arthroplasty for MC-KOA from September 2021 to September 2022.According to the preoperative doctor-patient communication,59 patients underwent UKA,while other 50 patients underwent TKA.The perioperative,follow-up and imaging data of the two groups were compared.[Results]The UKA group proved significantly superior to the TKA group in terms of operation time[(61.8±4.7)min vs(80.4±6.5)min,P<0.001],length of incision,[(5.7±0.3)cm vs(6.9±0.4)cm,P<0.001],intraoperative blood loss[(94.3±13.1)ml vs(147.5±19.8)ml,P<0.001],postoperative drainage volume[(169.8±10.0)ml vs(366.7±41.1)ml,P<0.001],time to regain active knee flex-ion of 90°[(13.8±2.2)days vs(17.1±2.4)days,P<0.001],and hospital stay[(9.8±1.8)days vs(14.4±2.4)days,P<0.001].As time went on,the VAS and KSS scores,knee extension-flexion ROM,stride speed,stride frequency and stride length were significantly improved in both groups(P<0.05).At the last follow-up,the UKA group was also significantly better than the TKA in terms of KSS score[(88.2±3.6)vs(82.7±3.1),P<0.001],knee extension-flexion ROM[(123.9±5.7)° vs(116.4±5.1)°,P<0.001],stride speed[(98.4±5.3)cm/s vs(85.1±5.9)cm/s,P<0.001],stride length[(89.3±10.1)cm vs(80.1±11.2)cm,P<0.001].As for imaging,femorotibial angle(FTA),hip-knee-ankle angle(HKA),medial proximal tibial angle(MPTA)and posterior tibial slope(PTS)were significantly improved in both groups at the last follow-up com-pared with those preoperatively(P<0.05).However,there were no significant differences in the above image indexes between the two groups at any corresponding time points(P>0.05).[Conclusion]Both UKA and TKA do achieve satisfactory clinical consequences for MC-KOA in elderly.In comparison,the UKA has more advantages in reducing surgical trauma,promoting functional recovery of knee joint and improving gait over the TKA.