[Objective]To compare clinical consequences of unilateral biportal endoscopic transforaminal lumbar interbody fusion(UBE-TLIF)versus minimal invasive transforaminal lumbar interbody fusion(MIS-TLIF)for multi-segment lumbar spinal stenosis(LSS).[Methods]A retrospective analysis was performed on 52 patients who received accurate minimal invasive surgery based on nerve block loca-tion for multi-level LSS in our hospitals from January 2022 to August 2023.According to preoperative doctor-patient communication,28 pa-tients were treated with UBE-TLIF,while other 24 patients underwent MIS-TLIF.The perioperative,follow-up and imaging data of the two groups were compared.[Results]All patients in both groups had operation performed successfully without serious complications,such as death and nerve injury.The UBE-TLIF group proved significantly superior to the MIS-TLIF group in terms of operative time[(137.7±24.6)min vs(154.8±34.5)min,P=0.042],intraoperative blood loss[(182.5±33.2)ml vs(211.7±57.4)ml,P=0.027],bed rest time[(2.4±0.5)days vs(3.3±0.4)days,P＜0.001],hospital stay[(7.3±1.4)days vs(8.4±2.1)days,P=0.042].As time went on during follow-up period lasted for(10.6±1.9)months in a mean,the VAS,ODI and JOA scores in both groups were significantly improved(P＜0.05),whereas which were not statisti-cally significant between the two groups at any corresponding time points(P＞0.05).As for imaging,the area of internal dural sac and height of intervertebral space at the responsible level were significantly improved in both groups after surgery(P＜0.05),while which were not signifi-cantly different between the two groups at any time points accordingly(P＞0.05).At the last follow-up,the intervertebral fusion rate was of 89.3％in the UBE-TLIF group,while 91.7％in the MIS-TLIF group,and the difference was not statistically significant(P＞0.05).[Conclu-sion]The accurate minimally invasive decompression and instrumented fusion in the treatment of multi-level lumbar spinal stenosis do sig-nificantly reduce surgical trauma and patients'economic burden.In contrast,UBE-TLIF group was superior to MIS-TLIF group in terms of operation time,intraoperative blood loss,bed rest and hospital stay.
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