[Objective]To compare the clinical outcomes of unilateral biportal endoscopy lumbar interbody fusion(UBE-LIF),versus minimally invasive surgery transforaminal lumbar interbody fusion(MIS-TLIF)for degree Ⅱ～Ⅲ lumbar spondylolisthesis.[Methods]From January 2019 to June 2022,a total of 249 patients who received surgical treatment for degree Ⅱ～Ⅲ spondylolisthesis were included in this study,and were divided into two groups according to random number table method.Of them,132 patients received UBE-LIF(the UBE group),while other 117 received MIS-TLIF(the MIS group).The perioperative,follow-up and imaging data of the two groups were com-pared.[Results]The operation was successfully completed in both groups without serious complications.The UBE group proved significant-ly superior to the MIS group in terms of intraoperative blood loss[(112.2±20.5)ml vs(132.9±25.8)ml,P＜0.001],intraoperative fluoroscopy times[(3.9±1.3)time vs(4.6±1.5)times,P＜0.001]and walking time after operation[(1.6±0.5)days vs(1.9±0.3)days,P＜0.001].The average follow-up time was of(15.0±3.0)months,and the UBE cohort resumed full weight-bearing activity significantly earlier than the MIS[(65.5±10.2)days vs(68.9±11.6)days,P=0.015].The VAS,ODI and JOA scores in both groups were significantly improved with the time after sur-gery(P＜0.05).The UBE group was significantly better than the MIS group in terms of VAS[(2.4±0.4)vs(2.7±0.6),P＜0.001],ODI[(29.2±6.7)vs(33.8±5.8),P＜0.001],JOA score[(20.3±3.7)vs(18.6±4.2),P＜0.001]3 months after surgery.Radiographically,the extent of slippage,intervertebral height,lumbar lordosis,and local Cobb angle significantly improved in both groups at the last follow-up compared with those preoperatively(P＜0.05),whereas which was not statistically significant between the two groups at any time points accordingly(P＞0.05).[Conclusion]UBE-LIF achieves clinical consequence similar to MIS-TLIF for degree Ⅱ～Ⅲ lumbar spondylolisthesis.However,the UBE-LIF has obvious advantages in reducing surgical trauma and improving short-term lumbar function over the MIS-TLIF.
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