Periprosthetic joint infection(PJI)is a serious complication after joint replacement,which requires a lot of medical resources and brings a huge economic burden to patients and society.In recent years,with the continuous development of novel molecular diagnostic techniques,the diagnosis and treatment of PJI have made great progress.Compared with traditional culture,the next-generation sequencing can diagnose pathogenic microorganisms quickly,accurately and comprehensively,and improve the detection rate of pathogenic microorgan-isms in PJI,so as to achieve early diagnosis and treatment of PJI.This paper reviews the principle and method of next-generation sequencing and its characteristics,advantages and limitations in identifying pathogenic microorganisms in PJI.
next generation sequencingperiprosthetic joint infectiondiagnosis
NETL
NSTL
万方数据
