IL-17在椎间盘退变中作用的研究现状
Current research status on the role of IL-17 in intervertebral disc degeneration
贾易臻 1梅胜锦 1杨家麟 1刘爱峰1
作者信息
- 1. 天津中医药大学第一附属医院国家中医针灸临床医学研究中心,天津 300381
- 折叠
摘要
椎间盘退变(intervertebral disc degeneration,IDD)是常见的临床疾病,随着人口老龄化的加重,其发病率逐年升高,给社会带来了沉重的经济负担.IDD发病机制复杂,涉及机械负载、炎症反应、自身免疫等多个方面.IL-17是辅助性T细胞17(T helper cell 17,Th17)的主要效应因子,参与炎症和自身免疫等多种生物过程.目前越来越多研究发现IL-17与IDD高度相关.IL-17可能通过促进细胞外基质(extracellular matrix,ECM)降解,加剧炎症反应,调节髓核细胞代谢,促进微血管生成等加速IDD进程.本文将对IL-17介导IDD的相关机制进行讨论,并对目前基于IL-17治疗IDD的研究现状进行综述.
Abstract
Intervertebral disc degeneration(IDD),a common clinical disease,brings serious economic burden to the society with the ag-gravation of population ageing.The pathogenesis of IDD is complex,involving many aspects,such as mechanical loading,inflammatory reac-tion,autoimmunity and so on.The IL-17 is a major effector of T helper cell 17(Th 17),and is involved in a variety of biological processes,in-cluding inflammation and autoimmunity.At present,more and more studies have found that the IL-17 is highly correlated with IDD,which may accelerate the process of IDD by promoting the degradation of extracellular matrix(ECM),exacerbating the inflammatory response,regu-lating the metabolism of nucleus pulposus cells,and promoting extracellular matrix angiogenesis.In this article,we will discuss the mecha-nism of IL-17-mediated IDD,and review the current research status of IL-17-based treatment of IDD.
关键词
IL-17/椎间盘退变/机制/治疗Key words
IL-17/intervertebral disc degeneration/mechanism/treatment引用本文复制引用
基金项目
基于"数智疗法"的运动康复VR系列设备应用研发项目(23KPXMRC00170)
天津市卫健委津门医学英才项目(TJSJ-MYXYC-D2-028)
出版年
2024
NETL
NSTL
万方数据