Intervertebral disc degeneration(IDD),a common clinical disease,brings serious economic burden to the society with the ag-gravation of population ageing.The pathogenesis of IDD is complex,involving many aspects,such as mechanical loading,inflammatory reac-tion,autoimmunity and so on.The IL-17 is a major effector of T helper cell 17(Th 17),and is involved in a variety of biological processes,in-cluding inflammation and autoimmunity.At present,more and more studies have found that the IL-17 is highly correlated with IDD,which may accelerate the process of IDD by promoting the degradation of extracellular matrix(ECM),exacerbating the inflammatory response,regu-lating the metabolism of nucleus pulposus cells,and promoting extracellular matrix angiogenesis.In this article,we will discuss the mecha-nism of IL-17-mediated IDD,and review the current research status of IL-17-based treatment of IDD.
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