N6-methyladenosine(m6A)is a reversible post-transcriptional modification that plays an important regulatory role in the life activities of all eukaryotes.In recent years,m6A methylation has been found to regulate bone development and bone homeostasis by modulating key genes such as RNA stabilization and translation efficiency.In this review,we summarize the current functional rolcs of m6A methylation and its related regulators in bone metabolism and osteoporosis,as well as the important advances of m6A methylation-related regulators as potential therapeutic targets.These findings will provide new directions and insights into the in-depth study of m6A methyla-tion in osteoporosis,as well as new strategies for the pharmacological treatment of osteoporosis.
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