骨质疏松症m6A甲基化修饰的研究进展
Progress of m6A methylation modification in osteoporosis
陈毅 1王耀斌 1牛永康 1夏亚一1
作者信息
- 1. 兰州大学第二医院骨科,甘肃兰州 730030
- 折叠
摘要
N6-甲基腺苷是一种可逆的转录后修饰,在所有真核生物的生命活动中起着重要的调节作用.近年来,研究发现甲基化通过调控RNA的稳定、翻译效率等关键基因,对骨发育和骨稳态进行调节.本综述总结了目前m6A甲基化及其相关调节因子在骨代谢和骨质疏松中的功能作用,以及m6A甲基化相关调控因子作为潜在治疗靶点的重要进展.这些发现将为m6A甲基化在骨质疏松症中的深入研究提供新的方向和认识,也为骨质疏松症的药物治疗提供了新的策略.
Abstract
N6-methyladenosine(m6A)is a reversible post-transcriptional modification that plays an important regulatory role in the life activities of all eukaryotes.In recent years,m6A methylation has been found to regulate bone development and bone homeostasis by modulating key genes such as RNA stabilization and translation efficiency.In this review,we summarize the current functional rolcs of m6A methylation and its related regulators in bone metabolism and osteoporosis,as well as the important advances of m6A methylation-related regulators as potential therapeutic targets.These findings will provide new directions and insights into the in-depth study of m6A methyla-tion in osteoporosis,as well as new strategies for the pharmacological treatment of osteoporosis.
关键词
m6A/骨质疏松/破骨细胞/成骨细胞/骨髓间充质干细胞Key words
m6A/osteoporosis/osteoclasts/osteoblasts/bone marrow mesenchymal stem cells引用本文复制引用
基金项目
国家自然科学基金项目(81874017)
国家自然科学基金项目(81960403)
国家自然科学基金项目(82060405)
兰州大学第二医院"萃英科技创新"计划项目(CY2021-MS-A07)
出版年
2024
NETL
NSTL
万方数据