[Objective]To investigate the efficacy and safety of dexamethasone used in perioperative period of femoral intertrochanter-ic fractures in elderly.[Methods]A total of 105 patients who underwent surgical treatments for femoral intertrochanteric fracture in our hos-pital from July 2021 to July 2023 were included and randomly divided into blank group,single-dose group and multiple-dose group by ran-dom number table method,with 35 cases in each group.The patients were given corresponding dexamethasone treatment in each group.The clinical and test data of the three groups were compared.[Results]All patients in the three groups had operation performed successful-ly.The multiple-dose group proved significantly superior to the blank group and single-dose group in terms of consumption of Tramadol[(60.4±13.2)mg vs(90.3±20.3)mg vs(75.4±17.6)mg,P＜0.001]and metoclopramide[(7.7±3.8)mg vs(13.1±5.1)mg vs(10.5±3.1)mg,P＜0.001].The incidence of perioperative nausea and vomiting was ranked as the multipl-dose group＜single-dose group＜blank group[cases(％),3(8.6)vs 7(20.0)vs 10(28.6),P＜0.001].The ICFS,PSQ1 and VAS in the three groups were significantly decreased 1 and 3 days after surgery compared with those preoperatively(P＜0.05).The multiple-dose group was significantly better than the blank group and single-dose group regarding PSQI score and VAS score(P＜0.05).In term of blood test,there were no statistically significant differences in WBC,CRP and IL-6 among the three groups before surgery(P＞0.05).However,the multiple-dose group and single-dose group proved significnt-ly superior to the blank group in WBC[(9.7±2.6)×109/L vs(10.5±2.4)×109/L vs(12.8±3.2)×109/L,P＜0.001],CRP[(19.2±6.9)mg/L vs(27.6±8.7)mg/L vs(39.4±10.2)mg/L,P＜0.001]and IL-6[(32.6±9.6)pg/ml vs(42.8±9.7)pg/ml vs(64.7±11.4)pg/ml,P＜0.001]3 days postopera-tively.[Conclusion]Multiple administrations of low-dose dcxamethasone during perioperative period of femoral intertrochanteric fractures not only reduce pain,improve sleep and relieve perioperative fatigue,but also does not increase the risk of hormone-related complications.
femoral intertrochanteric fracturedexamethasonerapid rehabilitationperioperative period
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