[Objective]To explore the predictive value of neutrophils/lymphocytes ratio(NLR)and C-reactive protein(CRP)/albumin(ALB)ratio(CRP/ALB)for postoperative infection of spinal surgery.[Methods]A total of 145 patients who underwent surgery for spinal dis-eases in our hospital from October 2018 to May 2022 were included into this study,with data collected.According to whether infection oc-curred within 7 days after operation,127 cases were fall into the uninfected group,while other 18 cases were in the infected group.Univari-ate comparison and binary multi-factor logistic regression analysis were used to analyze the related factors of infection.In addition,receiver operating characteristic curve(ROC)was used to evaluate the predictive value of NLR and CRP/ALB ratio for postoperative infection.[Re-sults]There was no significant difference in sex,body mass index(BMI)and surgical site between the two groups(P＞0.05),but infected group proved significantly greater than the uninfected group in terms of age[(67.2±5.8)years vs(58.3±4.6)years,P＜0.001],the operation time[(189.4±22.7)min vs(167.3±23.1)min,P＜0.001],blood transfusion ratio[Yes/No,(12/6)vs(52/75),P=0.040],internal fixation ratio[Yes/No,(10/8)vs(29/98),P=0.003],postoperative NLR[(7.5±2.0)vs(4.7±1.3),P＜0.001]and CRP/ALB[(3.5±0.6)vs(2.4±0.4),P＜0.001].As results of logistic regression analysis,the older age(OR=3.651,P=0.001),internal fixation(OR=2.362,P=0.003),CRP/ALB ratio(OR=2.324,P=0.002),elevated postoperative NLR(OR=1.681,P=0.011),longer operation time(OR=1.584,P=0.043),intraoperative blood trans-fusion(OR=1.333,P=0.003)were independent risk factors for postoperative infection.Regarding to ROC analysis,the areas under the ROC curve for predicting postoperative infection by NLR and CRP/ALB ratio alone,as well as combination of the two were of 0.857(95％ CI 0.785～0.934),0.956(95％ CI 0.898～1.000)and 0.982(95％ CI 0.912～1.000),respectively.[Conclusion]The NLR and CRP/ALB ratios are significantly increased in postoperative infection of spinal surgery,and both single one of them and their combination have predictive value for the infection.
postoperative infection of spinal surgeryneutrophil/lymphocyte ratioC-reactive protein/albumin ratiopredictive value
NETL
NSTL
万方数据
