[Objective]To evaluate the clinical efficacy of percutaneous endoscopic interlaminar discectomy(PEID)versus percutane-ous endoscopic transforaminal discectomy(PETD)for calcified lumbar disc herniation(cLDH).[Methods]PubMed,Web of science,EMS-CO,CNKI and Wanfang and VIP databases from January 1973 to February 2023 were searched to collect literatures on the comparison of PETD and PEID in the treatment of cLDH.A meta-analysis was performed with Revman 5.4 software.[Results]A total of 2 English litera-tures and 1 Chinese literatures were included in this study,involving a total of 161 patients,72 treated with PEID and 89 with PETD.As re-sults of the meta-analysis,the leg pain VAS scores[PEID group,(MD=6.58,95% CI 4.65~8.51,P<0.001);PETD group,(MD=6.40,95% CI 4.72~8.07,P<0.001)],and ODI score[PEID group,(MD=53.39,95% CI 50~56.78,P<0.001);PETD group(MD=52.34,95% CI 48.73~55.96,P<0.001)]were significantly improved at the latest follow-up compared with those preoperatively.However,there were no significant differences in VAS,ODI score,modified score and postoperative complication rate between the two groups at the last follow-up(P>0.05).[Conclusion]Both PEID and PETD can effectively treat calcified lumbar disc herniation,and there is no significant difference in efficacy and complication rate between PEID and PETD.