With the increase of age,intervertebral disc degeneration(IVDD)is an important cause of low back pain,which brings a huge economic burden to society.Many intrinsic factors,such as inflammation,oxidative stress,mitochondrial dysfunction,telomere shorten-ing,DNA damage,nutrient deprivation and epigenetic changes,etc,and extrinsic factors,including acute disc injury,excessive mechanical loading and long-term smoking,etc,have been shown to promote the aging of disc cells.In this paper,we summarized the relevant research progress of intervertebral disc cells and summarized the effects of some anti-aging interventions in delaying the disc cell aging in recent years,including senescent cell clearance,anti-inflammatory,antioxidant stress,telomerase transduction,growth factor supply and cell cycle blocking inhibitors,etc.These measures provide a new treatment strategy for delaying IVDD.
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