摘要
随着年龄的增长,椎间盘退变(intervertebral disc degeneration,IVDD)是导致腰痛的重要原因,给社会带来了巨大的经济负担.而退变的关键始动因素被认为是细胞衰老,许多内在(炎症反应、氧化应激、线粒体功能障碍、端粒缩短、DNA损伤、营养剥夺和表观遗传学改变等)和外在因素(急性椎间盘损伤、过度机械载荷和长期吸烟等)已被证明促进了椎间盘细胞的衰老.本文总结椎间盘细胞的相关研究进展,汇总了近年来一些针对抗衰老的干预措施在延缓椎间盘细胞衰老中的作用,包括衰老细胞清除、抗炎、抗氧化应激、端粒酶转导、生长因子供应和阻断细胞周期抑制剂等,这些措施为延缓IVDD提供了新的治疗策略.
Abstract
With the increase of age,intervertebral disc degeneration(IVDD)is an important cause of low back pain,which brings a huge economic burden to society.Many intrinsic factors,such as inflammation,oxidative stress,mitochondrial dysfunction,telomere shorten-ing,DNA damage,nutrient deprivation and epigenetic changes,etc,and extrinsic factors,including acute disc injury,excessive mechanical loading and long-term smoking,etc,have been shown to promote the aging of disc cells.In this paper,we summarized the relevant research progress of intervertebral disc cells and summarized the effects of some anti-aging interventions in delaying the disc cell aging in recent years,including senescent cell clearance,anti-inflammatory,antioxidant stress,telomerase transduction,growth factor supply and cell cycle blocking inhibitors,etc.These measures provide a new treatment strategy for delaying IVDD.
基金项目
浦东新区卫生系统学科带头人培养计划项目(PWRd2020-11)
上海市东方医院青年科研培育基金项目(DFPY2022003)
江西省自然科学基金重点项目(20212ACB206032)
江西省主要学科学术和技术带头人培养计划-领军人才项目(20213BCJ22011)
NETL
NSTL
万方数据