The cause of spinal disease is complex,while spinal operation is difficult with high risk of serious complication.The patient in the process of diagnosis and treatment will have different degrees of psychological and physiological changes,anxiety is more common and easy to be ignored.It has been reported that anxiety is related to the prognosis of patients and impacts the diagnosis and treatment process.In this paper,the causes of anxiety,the assessment tools of anxiety,the harm of anxiety to the perioperative period,as well the management and treatment strategies of anxiety were reviewed to provide new ideas and methods for further research about the influence of anxiety on the peri-operative spinal surgery.