[Objective]To explore the safety and clinical efficacy of unilateral biportal endoscopy(UBE)in the treatment of multilevel degenerative lumbar disease(MDLD).[Methods]Twenty nine patients who received surgical decompression with UBE for MDLD from July 2020 to June 2022 were retrospectively analyzed.The clinical and imaging data were evaluated.[Results]All the 29 patients successfully completed the operation,with the average operation time of(178.6±26.5)min,the average intraoperative fluoroscopy times of(10.9±2.9).In term of complication,dural tear happened in 2 cases,transient lower limb numbness in 2 cases,and epidural hematoma in 1 case,which not led serious consequence in anyone of them.The follow-up period lasted for(19.3±6.3)months in average.As time went from the point before surgery,to 7 days,3 months and 12 months postoperatively,the VAS score for pain[(6.6±1.5),(3.2±0.5),(2.1±0.6),(1.7±0.5),P＜0.001],ODI score[(58.6±11.2),(33.5±4.6),(22.8±3.8),(17.5±2.2),P＜0.001],JOA score[(15.6±2.4),(19.6±2.0),(21.2±2.2),(24.7±2.5),P＜0.001]signifi-cantly improved.At 12 months after operation,the excellent and good rate was of 86.2％ ,according to the modified MacNab criteria.In terms of imaging,there was a significant increase in spinal canal area at 12 months after surgery compared with that preoperatively[(58.3±9.6)mm2,(118.4±14.2)mm2,P＜0.001].The retention rate of facet joints was more than 60％ in all levels.[Conclusion]The UBE used in the treatment of MDLD does achieve satisfactory clinical outcomes,with a benefit to maintain the stability of lumbar spine by preserving more facet joints,is a safe and effective operation.
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