同种异体半月板移植临床结果的荟萃分析
Clinical results of meniscal allograft transplantation:a meta-analysis
焦颖 1刘伟 1亓建洪 1董军 1宋洪强1
作者信息
- 1. 山东第一医科大学运动医学与康复学院,山东泰安 271000
- 折叠
摘要
[目的]采用荟萃分析评估同种异体半月板移植(meniscal allograft transplantation,MAT)的临床效果.[方法]检索中国知网、中国生物医学文献、万方、维普、PubMed、Embase和Cochrane协作图书馆数据库自建库至2023年10月1日的文献,根据纳入标准收集MAT术后平均随访时间在10年及以上的文献.阅读全文提取效应量,通过RevMan 5.3软件进行荟萃分析.[结果]最终纳入10篇文献、382例患者,共计395个半月板移植物,平均随访时间13.4年.荟萃结果显示,术前与术后Tegner和VAS评分的差异均无统计学意义(P＞0.05).与术前相比,术后Lysholm评分(MD=-18.29,95％CI-26.33～-10.26,P＜0.001)、KOOS 评分[疼痛:(MD=-16.67,95％CI-28.63～-4.71,P=0.006);症状:(MD=-14.25,95％CI-26.52～-1.97,P=0.02);日常活动:(MD=-14.34,95％CI-21.33～-7.35,P＜0.001);运动和娱乐:(MD=-14.87,95％CI-24.84～-4.91,P=0.003);生活质量:(MD=-14.69,95％CI-26.48～-2.90,P=0.010)]、IKDC 评分(MD=-23.59,95％CI-27.42～-19.75,P＜0.001)、SF-36[身体功能:(MD=-15.98,95％CI-20.10～-11.87,P＜0.001);心理:(MD=-15.58,95％CI-20.97～-10.19,P＜0.001)]均显著增加,术后关节间隙显著减小(MD=0.88,95％CI0.60～1.15,P＜0.001).[结论]MAT具有良好的长期临床效果,可显著改善膝关节功能.
Abstract
[Objective]To evaluate the clinical outcomes of meniscal allograft transplantation(MAT).[Methods]The literatures were retrieved from CNKI,CBM,Wanfang,VIP,PubMed,Embase and Cochrane Collaborative Library databases up to October 1,2023.Accord-ing to the inclusion criteria,literatures with an average follow-up time of 10 years or more after MAT were collected.After reading the full pa-per and extracting the data met the including criteria,a meta-analysis was conducted by using Revman 5.3 software.[Results]Ten papers,involving 382 patients,and 395 menisci,were included,with a mean follow-up of 13.4 years.As meta analysis results,there were no statisti-cally significant differences in terms of Tegner and VAS scores after MAT surgery compared with those before surgery(P＞0.05).However,,Lysholm score(MD=-18.29,95％CI-26.33～-10.26,P＜0.001);KOOS score[pain:(MD=-16.67,95％CI-28.63～-4.71,P=0.006),symp-toms:(MD=-14.25,95％CI-26.52～-1.97,P=0.02),activities of daily living:(MD=-14.34,95％CI-21.33～-7.35,P＜0.001),sports and rec-reation:(MD=-14.87,95％CI-24.84～-4.91,P=0.003),quality of life:(MD=-14.69,95％CI-26.48～-2.90,P=0.010)];IKDC score(MD=-23.59,95％CI-27.42～-19.75,P＜0.001)and SF-36[physical health(MD=-15.98,95％CI-20.10～-11.87,P＜0.001)and mental health(MD=-15.58,95％CI-20.97～-10.19,P＜0.001)]increased significantly after MAT compared with those before surgery.[Conclusion]MAT has a good long-term clinical consequences,which does effectively improve knee joint function.
关键词
同种异体半月板移植/荟萃分析/保存/固定/临床结果Key words
meniscal allograft transplantation/meta-analysis/preservation/fixation/clinical outcomes引用本文复制引用
出版年
2024
NETL
NSTL
万方数据