[Objective]To compare the clinical consequence of unilateral biportal endoscopy transforaminal lumbar interbody fusion(UBE-TLIF)versus minimal invasive transforaminal lumbar interbody fusion(MIS-TLIF)for mild to moderate lumbar spondylolisthesis(LS).[Methods]A retrospective study was done on106 patients who had LS treated surgically in our hospital from January 2022 to March 2023.According to preoperative doctor-patient communication,50 patients received UBE-TLIF,while other 56 patients underwent MIS-TLIF.The documents regarding perioperative period,follow-up and images of the two groups were compared.[Results]Although the UBE-TLIF group consumed significantly longer operation time than the MIS-TLIF group[(145.0±31.2)min vs(124.8±20.5)min,P＜0.001],the for-mer proved significantly superior to the latter in terms of the total incision length[(3.4±0.5)cm vs(6.2±0.8)cm,P＜0.001],intraoperative blood loss[(113.54±30.8)ml vs(125.3±22.6)ml,P=0.026],intraoperative fluoroscopy times[(5.0±1.7)times vs(7.0±2.5)times,P＜0.001],walking time[(1.8±0.7)days vs(2.3±0.6)days,P＜0.001]and hospital stay[(6.2±1.8)days vs(7.5±2.6)days,P=0.004].With time of the fol-low-up lasted for(16.5±3.1)months in a mean,the VAS scores for back pain and leg pain,as well as ODI scores were significantly decreased(P＜0.05),while JOA scores were significantly increased in both groups(P＜0.05).The UBE-TLIF group proved significantly better than the MIS-TLIF group in back pain VAS score[(3.4±0.9)vs(4.0±1.0),P=0.002]1 week after surgery.With respect of imaging,compared with those preoperatively,the disc height(DH),lumbar lordosis(LL),foraminal area(FA),and vertebral spondylolisthesis percentage were signifi-cantly improved in both groups after surgery(P＜0.05).The UBE-TLIF group had significantly greater DH[(11.8±2.0)mm vs(11.0±1.8)mm,P=0.033]and FA[(13.4±2.0)mm2 vs(12.5±2.1)mm2,P=0.026]than the MIS-TLIF group one week after surgery.[Conclusion]UBE-TLIF achieve similar outcomes to MIS-TLIF in the treatment of single-segment mild to moderate LS,but UBE-TLIF has advantages of smaller in-cisions,less bleeding and faster early postoperative recovery over the MIS-TLIF.
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