[Objective]To compare the clinical consequence of unilateral biportal endoscopic discectomy(UBED)and percutaneous transforaminal endoscopic discectomy(PTED)in the treatment of single-segment lumbar disc herniation.[Methods]A retrospective re-search was done on 118 patients who had single-segment lumbar disc herniation treated by endoscopic surgery from January 2021 to De-cember 2021.According to preoperative doctor-patient communication,58 patients were treated with UBED,while other 60 patients were with PTED.The perioperative,follow-up and imaging data of the two groups were compared.[Results]All patients in both groups had oper-ation performed successfully.Although the UBED group had significantly less intraoperative fluoroscopy times[(1.4±0.5)vs(7.4±1.5),P<0.001]than the PTED group,there were no significant differences between the two groups in terms of operation time[(60.6±0.9)min vs(62.0±9.4)min,P=0.470],bed rest time[(1.7±0.5)days vs(1.6±0.6)days,P=0.705]and hospital stay[(4.4±1.0)days vs(4.4±0.9)days,P=0.862].However,the UBED group consumed significantly higher medical cost than the PTED group[(30.5±0.8)k-yuan vs(26.4±1.6)k-yu-an,P<0.001].As time went on,the VAS and ODI scores in both groups were significantly improved(P<0.05),which proved not significant-ly different between the two groups at any corresponding time points(P>0.05).Regarding imaging,the spinal canal occupied area ratio de-creased significantly in both groups at the last follow-up compared with that preoperatively(P<0.05),while the intervertebral space height and lumbar lordotic angle remained unchanged significantly(P>0.05).[Conclusion]UBED achieves comparable clinical outcome to PTED in the treatment of single-segment lumbar disc herniation,although UBED has less fluoroscopic radiation,while more hospitalization costs over the PTED.