Objective To explore the application effect of virtual scenario simulation training system in interventional radiology experiment teaching.Methods A total of 603 students who participated in the experimental course of interventional radiology in Bengbu Medical University from September 2022 to June 2023 were selected as the research objects.Interventional radiology experiment teaching was conducted by using the virtual scenario simulation training system constructed by the Department of Radiology Paper approach to understand students'evaluation of the system.Result All 603 students scored more than 60 points,of which 100(16.58%)students scored 60-69 points,157(26.04%)students scored 70-79 points,164(27.20%)students scored 80-89 points,and 182(30.18%)students scored≥90 points,with an average score of(81.95±11.07)points.In terms of mastering the situation,97.84%(590/603)students were familiar with the equipment related to interventional test,95.52%(576/603)students said they knew the specific operation of interventional surgery,and 91.87%(554/603)students thought they could complete the operation.In terms of system advantages,99.17%(598/603)students believed that the system could prevent teachers and students from being harmed by radiation,97.35%(587/603)students believed that the system could reduce errors and risks in actual surgery and the risk of contamination caused by entering the operating room for observation,thus ensuring the health of patients.89.22%(538/603)of the students thought it could save materials and costs.In terms of system deficiencies,31.01%(187/603)students thought that the software would appear to be delayed,27.86%(168/603)students think that the steps were too many,easy to reverse the order,59.54%(359/603)of the students thought that they lack the feel of real operation on the operating table.Conclusion The virtual scenario simulation training system has the characteristics of novel form,convenient and fast,strong interactivity,open platform and mobility,which can cultivate students'innovative spirit,dialectical thinking and hands-on ability,and strengthen the training of students'clinical practice operation skills.