中国康复理论与实践2024，Vol.30Issue(1) ：21-28.DOI:10.3969/j.issn.1006-9771.2024.01.003

多靶区经颅直流电刺激对健康成年人工作记忆-姿势控制双任务表现的影响

Effect of multi-target transcranial direct current stimulation on performance of working memory-postural con-trol dual-task in healthy adults

周治宁 周容 肖燕文 王博文 吕娇娇 刘宇
中国康复理论与实践2024，Vol.30Issue(1) ：21-28.DOI:10.3969/j.issn.1006-9771.2024.01.003
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多靶区经颅直流电刺激对健康成年人工作记忆-姿势控制双任务表现的影响

Effect of multi-target transcranial direct current stimulation on performance of working memory-postural con-trol dual-task in healthy adults

周治宁 1周容 1肖燕文 2王博文 1吕娇娇 1刘宇1
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作者信息

  • 1. 上海体育大学运动健身科技省部共建教育部重点实验室,上海市 200438
  • 2. 上海体育大学运动健身科技省部共建教育部重点实验室,上海市 200438;中山大学孙逸仙纪念医院深汕中心医院,广东汕尾市 516600
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摘要

目的 探究多靶区经颅直流电刺激(tDCS)和单靶区tDCS对健康成年人工作记忆-姿势控制双任务表现的影响,并比较两种刺激方案的调控效果.方法 2020年11月至2021年2月,招募上海体育大学19例健康成年人,随机接受多靶区tDCS、单靶区tDCS和假刺激,任意两种刺激之间至少间隔1周.其中,多靶区tDCS的目标靶区为左侧背外侧前额叶(L-DLPFC)和双侧初级运动皮质(M1);单靶区tDCS仅刺激L-DLPFC.在每种刺激前后,所有受试者进行单任务和双任务条件下的步行和站立平衡测试,双任务中的第二任务为N-back任务.刺激前后观察双任务姿势控制表现、双任务消耗(DTC)和工作记忆表现.结果 刺激后,3种刺激间双任务步行的步幅变异性(F = 3.792,P = 0.029)、步幅变异性_DTC(F = 3.412,P = 0.040)以及双任务站立平衡的压心摆动速度(Vcop)(F = 3.815,P = 0.029)有显著性差异.与假刺激相比,多靶区tDCS后,步幅变异性(P = 0.047)和Vcop(P = 0.015)降低,步幅变异性_DTC有降低趋势(P = 0.073);单靶区tDCS后,步幅变异性(P = 0.011)、步幅变异性_DTC(P = 0.014)和Vcop(P = 0.025)均降低.与单靶区tDCS相比,多靶区tDCS后,压心摆动面积的双任务消耗降低(P = 0.035).3种刺激后受试者工作记忆表现改变无显著性差异(P>0.05).结论 多靶区tDCS和单靶区tDCS均可调控健康成年人的工作记忆-姿势控制双任务表现;且与单靶区tDCS相比,多靶区tDCS在调控站立平衡双任务姿势控制效果上具有一定优势.

Abstract

Objective To investigate the effect of multi-target transcranial direct current stimulation(tDCS)and single-target tDCS on the performance of working memory-postural control dual-task in healthy adults,and to compare the regulato-ry effect of the two stimulation protocols.Methods From November,2020 to February,2021,19 healthy adults in Shanghai University of Sport were recruited and randomly accepted multi-target tDCS,single-target tDCS and sham stimulation with at least one week interval be-tween any two stimulation protocols.The target areas of multi-target tDCS included left dorsal lateral prefrontal cortex(L-DLPFC)and bilateral primary motor cortex(M1),and single-tDCS only applied to L-DLPFC.Before and after stimulation,participants completed walking and standing balance tests under single task and dual-task conditions with the second task being a N-back task.The dual-task postural control performance,dual-task cost(DTC)and working memory performance were observed before and after stimulation.Results Significant differences were observed among three stimulation protocols in the changes of stride variability(F = 3.792,P = 0.029),DTC of stride variability(F = 3.412,P = 0.040)and velocity of center of pressure(Vcop)(F = 3.815,P = 0.029).The stride variability(P = 0.047)and Vcop(P = 0.015)were significantly lower and the de-crease in DTC of stride variability tended to be significant(P = 0.073)following multi-target tDCS,as compared to sham stimulation.Single-target tDCS significantly decreased the changes of stride variability(P = 0.011),DTC of stride variability(P = 0.014)and Vcop(P = 0.025),as compared to sham stimulation.Compared with single target tDCS,multi-target tDCS reduced the changes of the dual-task cost of the area of center of pressure(P = 0.035).Moreover,no significant difference was observed among the three stimulation protocols in the changes of each measure in the working memory test(P>0.05).Conclusion Both multi-target tDCS and single-target tDCS can improve the performance of working memory-postural control dual-task in healthy adults,and compared with single-target tDCS,multi-target tDCS has some advantag-es in regulating postural control.

关键词

双任务/姿势控制/工作记忆/背外侧前额叶/初级运动皮质/经颅直流电刺激

Key words

dual-task/postural control/working memory/dorsal lateral prefrontal cortex/primary motor cortex/transcranial direct current stimulation

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基金项目

国家自然科学基金项目(11932013)

国家自然科学基金项目(12302418)

上海市体育科技项目(24J013)

出版年

2024
中国康复理论与实践
中国残疾人康复协会,中国医师协会,中国康复研究中心

中国康复理论与实践

CSTPCD北大核心
影响因子：1.354
ISSN：1006-9771
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