Effect of multi-target transcranial direct current stimulation on performance of working memory-postural con-trol dual-task in healthy adults
Objective To investigate the effect of multi-target transcranial direct current stimulation(tDCS)and single-target tDCS on the performance of working memory-postural control dual-task in healthy adults,and to compare the regulato-ry effect of the two stimulation protocols.Methods From November,2020 to February,2021,19 healthy adults in Shanghai University of Sport were recruited and randomly accepted multi-target tDCS,single-target tDCS and sham stimulation with at least one week interval be-tween any two stimulation protocols.The target areas of multi-target tDCS included left dorsal lateral prefrontal cortex(L-DLPFC)and bilateral primary motor cortex(M1),and single-tDCS only applied to L-DLPFC.Before and after stimulation,participants completed walking and standing balance tests under single task and dual-task conditions with the second task being a N-back task.The dual-task postural control performance,dual-task cost(DTC)and working memory performance were observed before and after stimulation.Results Significant differences were observed among three stimulation protocols in the changes of stride variability(F = 3.792,P = 0.029),DTC of stride variability(F = 3.412,P = 0.040)and velocity of center of pressure(Vcop)(F = 3.815,P = 0.029).The stride variability(P = 0.047)and Vcop(P = 0.015)were significantly lower and the de-crease in DTC of stride variability tended to be significant(P = 0.073)following multi-target tDCS,as compared to sham stimulation.Single-target tDCS significantly decreased the changes of stride variability(P = 0.011),DTC of stride variability(P = 0.014)and Vcop(P = 0.025),as compared to sham stimulation.Compared with single target tDCS,multi-target tDCS reduced the changes of the dual-task cost of the area of center of pressure(P = 0.035).Moreover,no significant difference was observed among the three stimulation protocols in the changes of each measure in the working memory test(P>0.05).Conclusion Both multi-target tDCS and single-target tDCS can improve the performance of working memory-postural control dual-task in healthy adults,and compared with single-target tDCS,multi-target tDCS has some advantag-es in regulating postural control.
dual-taskpostural controlworking memorydorsal lateral prefrontal cortexprimary motor cortextranscranial direct current stimulation
万方数据
维普
