Effect of high-frequency repetitive transcranial magnetic stimulation in M1 region combined with dorsolateral prefrontal cortex on electroencephalogram θ frequency band amplitude of patients with neuropathic pain after spinal cord injury
Objective To explore the efficacy of high-frequency repetitive transcranial magnetic stimulation(rTMS)in M1 region combined with dorsolateral prefrontal cortex(DLPFC)on electroencephalogram(EEG)θ frequency band ampli-tude of patients with neuropathic pain(NP)after spinal cord injury.Methods From June,2022 to June,2023,50 NP patients after SCI in Qingdao University Affiliated Hospital were includ-ed and divided into M1 region stimulation group(n = 25)and M1 region combined with DLPFC stimulation group(the combined stimulation group,n = 25).M1 region stimulation group received 10 Hz rTMS in the left M1 region,while the combined stimulation group received same stimulation in left M1 region combined with DLPFC,for three weeks.Before and after intervention,the pain was assessed with Short Form of McGill Pain Questionnaire(SF-MPQ),the depression and anxiety status were evaluated using Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA),and the EEG θ frequency band amplitude was recorded to detect the changes of brain electrophysiological activity.Results Four cases in M1 region stimulation group,and two cases in the combined stimulation group were dropped.Af-ter intervention,the total score of SF-MPQ and the scores of the subscales,the scores of HMMD and HAMA de-creased in both groups(|t|>2.523,P<0.05).The EEG θ frequency band amplitude significantly reduced in the prefrontal and frontal regions in M1 region stimulation group(|t|>5.243,P<0.001),and it also significantly re-duced in the prefrontal,frontal regions,central and parietal regions in the combined stimulation group(|t|>4.630,P<0.001).All the scores were lower(|t|>2.270,Z =-1.973,P<0.05),and the EEG θ frequency band amplitude in the prefrontal,frontal regions,central and parietal regions were lower(P<0.05)in the combined stimulation group than in M1 region stimulation group.Conclusion High frequency rTMS is an effective analgesic method on NP after SCI,which can improve their depression and anxiety symptoms and reduce the EEG θ frequency band amplitude.Compared with M1 region rTMS stimu-lation,the combination of M1 region and DLPFC rTMS is more effective.
spinal cord injuryneuropathic painrepetitive transcranial magnetic stimulationelectroencephalogramθ frequency band amplitude
万方数据
维普
