Effect of transcranial direct current stimulation on cognitive function and quality of life in patients with Parkin-son's disease:a meta-analysis
Objective To evaluate the effect of transcranial direct current stimulation(tDCS)on the cognitive function and quality of life in patients with Parkinson's disease.Methods Randomized controlled trials(RCTs)on tDCS for Parkinson's disease were searched in PubMed,Web of Sci-ence,Embase,Cochrane Library,CNKI,CBM,VIP and Wanfang Data from the inception to September,2023.Control group was administered standard Parkinson's medications or placebo,physical therapy,and cognitive re-habilitation,while treatment group received tDCS additionally.The quality of the researches was evaluated using the Cochrane Risk of Bias Tool.Data synthesis and analysis were performed using RevMan 5.4 and Stata 17.0,with heterogeneity and sensitivity analyses.Results Eight articles were included.tDCS significantly improved the scores of Montreal Cognitive Assessment(MD = 2.00,95%CI 1.13 to 2.87,P<0.001).However,there was no significant difference in the scores of Parkinson's Disease Questionnaire(MD = 0.73,95%CI-5.78 to 7.23,P = 0.830),Beck Depression Inventory-Ⅱ(MD =-0.77,95%CI-7.14 to 5.60,P = 0.810),and Unified Parkinson Disease Rating Scale-Ⅲ(MD = 1.60,95%CI-0.77 to 3.97,P = 0.190).Conclusion tDCS may improve cognitive function of patients with Parkinson's disease.
Parkinson's diseasecognitive impairmenttranscranial direct current stimulationmeta-analysis
国家科技期刊平台
NSTL
万方数据
维普
