Impact of autonomic nerve function on motor function in patients with post-stroke depression
Objective To explore the impact of autonomic nerve function on motor function in patients with post-stroke depression(PSD)from the perspective of regional homogeneity(ReHo).Methods From January to December,2020,a total of 60 inpatients and outpatients with cerebral infarction in the Affiliat-ed Brain Hospital of Nanjing Medical University were divided into control group(n = 30)and PSD group(n =30).Two groups were assessed using Fugl-Meyer Assessment(FMA),modified Barthel Index(MBI)and Hamil-ton Depression Scale(HAMD).Heart rate variability(HRV)was measured.Ten patients in each group were se-lected randomly to undergo resting state functional magnetic resonance imaging(rs-fMRI)to calculate ReHo.Results All HRV indices were lower in PSD group than in the control group(|t|>2.092,P<0.05).In PSD group,FMA and MBI scores showed positive correlations with 24-hour standard deviation of normal-to-normal R-R intervals(SDNN),the root mean square of successive differences between normal heartbeats over 24 hours(RMSSD),the percentage of differences between adjacent normal R-R intervals over 24 hours that were greater than 50 ms(PNN50),total power(TP),very low frequency power(VLF)and low frequency power(LF)(r>0.394,P<0.05),and showed negative correlations with HAMD scores(|r|>0.919,P<0.001).HAMD scores in PSD group were negatively correlated with SDNN,RMSSD,PNN50,TP and VLF(|r|>0.769,P<0.001).Compared with the control group,the ReHo increased in PSD group in the right rectus gyrus(142 voxels,t = 6.575),the left me-dial and paracingulate gyri(204 voxels,t = 4.925)(GRF correction,P-Voxel<0.005,P-Cluster<0.05);and reduced in the right cerebellum(191 voxels,t =-6.487),the left middle temporal gyrus(140 voxels,t =-5.516),and the left precentral gyrus(119 voxels,t =-4.764)(GRF correction,P-Voxel<0.005,P-Cluster<0.05)in PSD group.Conclusion Autonomic nerve function is related to motor dysfunction in patients with PSD.The modulation of emo-tional,cognitive and motor brain regions by the autonomic nervous system may play a role in influencing the mo-tor function in patients with PSD.
post-stroke depressionheart rate variabilityautonomic nervefunctional magnetic resonance imagingregional homogeneity
国家科技期刊平台
NSTL
万方数据
维普
