摘要
目的 观察伴或不伴冻结步态的早中期帕金森病患者运动功能和生活质量的差异,分析冻结步态与患者运动功能和生活质量的相关性.方法 2021年4月至2022年12月,在北京协和医学院门诊选取60～80岁早中期帕金森病患者132例,根据是否并发冻结步态分为冻结步态组(n = 43)和非冻结步态组(n = 89).采用冻结步态问卷(FOGQ)、Berg平衡量表(BBS)、计时起立-行走测试(TUGT)、5次起坐试验(FTSST)、等速肌力测试、统一帕金森病评分量表(UPDRS)和39项帕金森病生活质量问卷(PDQ-39)进行评定.结果 冻结步态组BBS评分小于非冻结步态组(Z =-2.354,P<0.05),TUGT、FTSST、UPDRS第二和第三部分评分以及帕金森病生活质量指数(PDSI)明显大于非冻结步态组(Z>3.074,t = 2.748,P<0.01).FOGQ评分与BBS、UPDRS第二和第三部分评分,以及PDSI显著相关(|r|>0.392,P<0.001).结论 冻结步态的发生影响早中期帕金森病患者的运动功能、日常生活活动能力和生活质量,增加跌倒风险.
Abstract
Objective To observe the differences in motor function and quality of life among mild-to-moderate Parkinson's disease(PD)patients with or without freezing of gait(FOG),and the correlation of FOG to motor function and quality of life.Methods From April,2021 to December,2022,132 mild-to-moderate PD patients aged 60 to 80 years were selected from Peking Union Medical College Hospital,and were divided into FOG group(n = 43)and non-FOG group(n = 89)according to the clinical features.They were assessed with Freezing of Gait Questionnaire(FOGQ),Berg Balance Scale(BBS),Timed"Up&Go"Test(TUGT),Five Times Sit to Stand Test(FTSST),isokinetic muscle strength,Unified Parkinson's Disease Rating Scale(UPDRS)and 39-item Parkinson's Disease Question-aire-39(PDQ-39).Results The BBS score was lower(Z =-2.354,P<0.05),and the TUGT,FTSST,UPDRS part 2 and part 3 scores,and the Parkinson's disease summary index(PDSI)were higher in FOG group than in non-FOG group(Z>3.074,t = 2.748,P<0.01).FOGQ score correlated with BBS score,UPDRS Part 2 and Part 3 scores,and PDSI(|r|>0.392,P<0.001).Conclusion FOG would impair motor function,activities of daily living and quality of life in mild-to-moderate PD pa-tients,and increase the risk of falls.
基金项目
北京市科技委员会老龄科技服务创新能力提升项目(Z191100004419009)
维普
万方数据