健康人和脑卒中患者视觉反馈步行训练后脑激活特征的功能性近红外光谱技术研究
Characteristics of brain activation during treadmill walking with visual feedback in healthy subjects and hemiple-gic patients:a functional near infrared spectroscopy study
谢丹丹 1陈善佳 1雷蕾 1余果 1余佳慧 1赵嘉培 1何晓阔2
作者信息
- 1. 厦门市第五医院康复医学科,福建厦门市 361101
- 2. 厦门市第五医院康复医学科,福建厦门市 361101;厦门市脑病康复技术转化重点实验室,福建厦门市 361101
- 折叠
摘要
目的 比较健康受试者和脑卒中患者在视觉反馈步行训练(TWVF)时的皮质激活特征.方法 2021年8月至11月,厦门市第五医院招募8例脑卒中右侧偏瘫住院患者(患者组)和8例健康受试者(健康组).两组均佩戴功能性近红外光谱帽并完成TWVF任务,范式包括预备期(10 s)和任务期("迈步30 s-休息30 s"5个循环).测量两组大脑皮质激活β值,感兴趣区(ROI)包括前运动皮质(PMC)、辅助运动区(SMA)、感觉运动皮质(S1与M1合称SMC).结果 健康组步行时双侧M1无明显激活,左半球SMA、PMC和S1激活(P<0.05);患者组步行时健(右)侧半球M1激活程度高于患(左)侧半球,PMC激活程度低于患侧(P<0.05).患者组双侧半球M1、健侧SMA和患侧PMC的激活程度高于健康组(P<0.05).结论 脑卒中偏瘫患者在步行时涉及更多的SMC-PMC-SMA运动网络激活.健康受试者步行时无明显M1激活,偏瘫患者健侧M1存在代偿激活现象.
Abstract
Objective To compare the cortical activation characteristic in the healthy subjects and hemiplegia patients during execut-ing treadmill walking with visual feedback(TWVF).Methods From August to November,2021,eight stroke patients with right hemiplegia(patient group)and eight healthy subjects(healthy group)in Fifth Hospital of Xiamen were recruited.Both groups wore functional near-infrared spectroscopy(fNIRS)caps and executed TWVF,respectively.Experimental block design for walking modes in-cluded the preparation period(10 s)and task period(five cycles of"step 30 s-rest 30 s").The cortical activation(β values)were measured.The regions of interest(ROI)included the pre-motor cortex(PMC),supplementary motor area(SMA),primary motor cortex(M1),primary somatosensory cortex(S1)and sensorimotor cortex(SMC,M1+S1).Results No activation in bilateral M1,and some significant activation(P<0.05)in the left hemisphere SAM,PMC and S1,were found during walking in the healthy group.M1 was activated more in the unaffected(right)hemisphere than in the affected(left)hemisphere during walking in the patient group(P<0.05),and less PMC activation was found(P<0.05).M1 in bilateral hemispheres,SMA in the unaffected hemisphere and PMC in the affected hemi-sphere were activated more in the patient group than in the healthy group(P<0.05).Conclusion The locomotor network of SMC-PMC-SMA are activated more in the hemiplegic patients than in the healthy pepole during walking.M1 are almost not activated in the healthy people during walking,and compensa-torily activated in M1 of the unaffected side in the hemiplegic patients.
关键词
脑卒中/步行/脑激活模式/功能性近红外光谱技术Key words
stroke/walking/brain activation/functional near infrared spectroscopy引用本文复制引用
基金项目
厦门市医疗卫生重点项目(3502Z20234005)
厦门市自然科学基金项目(3502Z202373135)
厦门市自然科学基金项目(3502Z20227418)
福建省自然科学基金项目(2022D010)
出版年
2024
国家科技期刊平台
NSTL
万方数据