Objective To investigate the factors related to the abandonment of upper limb prostheses.Methods A total of 138 amputees fitting with upper limb prostheses at Guangdong Work Injury Rehabilitation Hospital from January 1st,2016 to December 31st,2022 were reviewed through case data,and those whose Functional In-dependence Measure scores improved after fitting were selected.A total of 126 amputees were investigated through telephone or WeChat with a questionnaire.The questionnaire was designed based on Trinity Amputation and Prosthesis Experience Scale-Revised,short form of Health Survey(SF-36)and World Health Organization Quality of Life Scale-Brief,and the items that may lead to the abandonment of upper limb prostheses were sum-marized in four factors:amputee,prosthetic fitting,prosthetic training,and environment and social policy.Results The overall abandonment rate was 23.0%(29/126).There was significant difference between the the amputee abandonment or using prostheses in educational levels,amputation levels and residual limb condition(χ2>6.808,P<0.05);types of prostheses,whether functional prostheses,expectation for prosthesis,comfort of the prosthe-ses,convenience of putting on and taking off,sensitivity of manipulation,weight of the prostheses,satisfaction with the appearance,skill levels of the prosthetist,the satisfaction after prosthesis installation and satisfaction with the prostheses in use(χ2>13.083,P<0.05);training levels before prosthesis assembly,the mastery of func-tional prostheses three months after prosthesis installation,training for activities of daily living,simulated train-ing for vocation(χ2>6.520,P<0.05);willingness to participate in social activities with prostheses,attitude of other persons towards their prostheses,support of family members,work status,familiarity with the policies of welfare,and the current physical condition(χ2>13.152,P<0.01).Conclusion Factors of amputee,prosthetic fitting,prosthetic training,and environment and social policy may relate to the abandonment of upper limb prostheses,which are needed to improve in an accurate way.