Effects of type 2 diabetes on cognitive function and hippocampus structure in patients with subjective cog-nitive decline
Objective:To investigate the effect of type 2 diabetes mellitus(T2DM)disease status on cognitive function in patients with subjective cognitive decline(SCD),and to explore possible mechanisms based on the structural features of the hippocampus.Method:According to their T2DM disease status,voluntary and eligible SCD subjects in the community of Fu-zhou city,Fujian province were recruited and divided into SCD patients with T2DM and SCD patients with-out T2DM.The effects of different T2DM disease status on cognitive performance scores,hippocampal vol-ume,hippocampal subregion volume and parahippocampal surface area in patients with SCD were compared,and the correlation analysis was performed between the significantly different cognitive performance scores and the hippocampal volume,hippocampal subregion volume and parahippocampal surface area.Result:Compared with SCD patients without T2DM,SCD patients with T2DM had a longer Stroop facilitation effect(SFE)response time,fewer SFE correct numbers,more Go/No go errors,and distracted visual response time was longer.The difference was statistically significant(P＜0.05).Analysis of MRI data showed that the volume and parahippocampal surface area of the left hippocampal subregion of SCD patients with T2DM were significantly lower than those of SCD patients without T2DM.The results of correlation analysis showed that the parahippocampal surface area of SCD patients was significantly positively correlated with the correct num-ber of SFE(P＜0.001).Conclusion:T2DM aggravates cognitive impairment in Stroop facilitation effect,executive inhibitory control function,and cognitive processing domains of visual distraction in SCD patients,and may be related to the at-rophy of gray matter structure in some brain regions of the hippocampus.
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