变频相位干涉电场刺激对运动皮层兴奋性及运动学习表现的影响
Effects of variable frequency temporal interference electrical fields stimulation on motor cortex excitabili-ty and motor learning performance
闫金龙 1朱春月 1付田莉 1黄灵燕 1吕娇娇 1刘宇1
作者信息
- 1. 上海体育大学"运动健身科技"省部共建教育部重点实验室,上海,200438
- 折叠
摘要
目的:探究变频相位干涉电场刺激(temporal interference electrical fields stimulation,TI)对健康成年人运动皮层兴奋性及运动学习能力的影响,为TI刺激的应用提供依据.方法:采用随机交叉双盲设计,研究对象为健康成年人.试验1:20例受试者完成经颅磁刺激(transcranial magnet-ic stimulation,TMS)测试,评估刺激前后皮层兴奋性指标的改变,包括运动诱发电位(motor evoked potential,MEP)、静息运动阈值(resting motor threshold,RMT)、短时距皮层内抑制(short-interval intracortical inhibition,SICI)、皮质内促通(intracortical facilitation,ICF).试验2:16例受试者完成随机反应时任务(random reaction time task,RRTT)和序列反应时任务(serial reaction time task,SRTT),测试指标包括平均反应时(reaction time,RT)、第一内隐学习(first implicit learning,FIL)、第二内隐学习(second implicit learning,SIL).通过双因素重复测量方差分析评价TI刺激对受试者运动皮层兴奋性及运动学习能力的影响.结果:试验 1:刺激条件和时间对 MEP(F=28.787,P＜0.001,ηP2=0.602)和RMT(F=23.524,P＜0.001,ηP2=0.580)具有显著交互作用,而SICI和ICF无显著交互效应.试验2:与假刺激相比,TI刺激后SRTT中的FIL有显著提升(F=4.601,P=0.049,ηP2=0.235),而 RRTT任务则无显著交互效应.结论:变频TI刺激可以显著增加初级运动皮层的兴奋性,这种调控效应可能有助于促进健康成年人运动学习表现.
Abstract
Objective:To investigate the effects of temporal interference electrical fields(TI)on motor cortical excitabili-ty and motor learning abilities in healthy adults,in order to provide evidence for the application of TI stimula-tion in human.Method:A randomized crossover double-blind design was used with healthy adults participants.Experiment l:twenty subjects completed transcranial magnetic stimulation(TMS)testing to assess changes in cortical excit-ability indicators before and after stimulation,including motor evoked potentials(MEP),resting motor thresh-old(RMT),short-interval intracortical inhibition(SICI),and intracortical facilitation(ICF).Experiment 2:sixteen subjects completed the random reaction time task(RRTT)and the serial reaction time task(SRTT),with performance indicators including average reaction time(RT),first implicit learning(FIL),and second im-plicit learning(SIL).The effects of TI stimulation on cortical excitability and motor learning abilities were evaluated using a two-factor repeated measures analysis of variance.Result:Experiment 1:there were significant interactions between stimulation condition and time on MEP(F=28.787,P＜0.001,ηP2=0.602)and RMT(F=23.524,P＜0.001,ηP2=0.580),while SICI and ICF showed no significant interaction effects.Experiment 2:compared to sham stimulation,FIL in SRTT was significantly im-proved after TI stimulation(F=4.601,P=0.049,ηP2=0.235),while there was no significant interaction effect in the RRTT task.Conclusion:Variable frequency TI stimulation can significantly increase cortical excitability in the primary mo-tor cortex,and this regulatory effect may contribute to enhancing motor learning performance in healthy adults.
关键词
相位干涉电场刺激/初级运动皮层/运动诱发电位/运动学习Key words
phase-interferometric electric field stimulation/primary motor cortex/motor evoked potentials/mo-tor learning引用本文复制引用
出版年
2024
NETL
NSTL
万方数据