目的:利用事件相关电位(event-related potential,ERP)P300探讨为期12周太极拳联合经颅直流电刺激(transcrani-al direct current stimulation,tDCS)对轻度认知障碍(mild cognitive impairment,MCI)患者认知功能的影响.方法:将79例MCI患者随机分为4组:太极拳+tDCS组20例,接受太极拳训练联合阳极tDCS刺激;太极拳+伪tDCS组20例,接受太极拳训练联合伪tDCS刺激;健步走+tDCS组19例,接受健步走训练联合tDCS刺激;健步走+伪tDCS组20例,接受健步走训练联合伪tDCS刺激.干预周期为每周3次,每次lh,持续12周.干预前后采用蒙特利尔认知功能评估量表(Montreal cognitive assessment,MoCA)评估整体认知功能,中文版韦氏成人记忆量表评估记忆功能,同时记录ERP-P300波幅和潜伏期的变化.结果:①12周干预后太极拳+tDCS组MoCA评分显著高于健步走+伪tDCS组(P=0.009);太极拳+tDCS组记忆商评分显著高于太极拳+伪tDCS组(P=0.010)、健步走+tDCS组(P=0.004)及健步走+伪tDCS组(P=0.008).②12周干预后太极拳+tDCS组Pz、Cz电极处波幅显著高于健步走+伪tDCS组(P分别为＜0.001、0.001),太极拳+tDCS组Fz波幅显著高于健步走+tDCS组(P=0.011)及健步走+伪tDCS组(P=0.002).③偏相关分析结果显示,MoCA总分变化与Fz电极处波幅变化存在相关性(r=0.261,P=0.034).结论:为期12周太极拳联合tDCS的干预可以改善MCI患者认知功能,增加ERP-P300在Pz波幅、Fz波幅、Cz电极处波幅,且整体认知功能的改变可能与Fz电极处波幅的变化有关.
Effects of Tai Chi combined with transcranial direct current stimulation on P300 event-related potential in patients with mild cognitive impairment
Objective:To evaluate the effects of 12 weeks of Tai Chi combined with transcranial direct current stimula-tion(tDCS)on cognitive functioning in patients with mild cognitive impairment(MCI)using event-related po-tential(ERP)-P300.Method:Seventy-nine patients with MCI were randomly divided into 4 groups:Tai Chi+tDCS group(n=20)received Tai Chi training combined with anodic tDCS;Tai Chi+sham tDCS group(n=20)received Tai Chi training combined with sham tDCS;walking+tDCS group(n=19)received walking training combined with tDCS;walking+sham tDCS group(n=20)received walking combined with sham tDCS group.The dura-tion of the intervention was 3 times per week,1 hour/session,for 12 weeks.All participants were assessed at baseline and 12 weeks for global cognitive function,memory,ERP-P300 wave amplitude and latency.Result:After 12 weeks of intervention,the MoCA score of Tai Chi+tDCS group were significantly higher than walking+sham tDCS group(P=0.009);the MQ score of Tai Chi+tDCS group were significantly high-er than Tai Chi+sham tDCS group(P=0.010),walking+tDCS group(P=0.004)and walking+sham tDCS group(P=0.008).P300 amplitudes at the Pz amplitude and Cz amplitude of Tai Chi+tDCS group were significantly higher than walking+sham tDCS group(P＜0.00l,P=0.001),the Fz amplitude of Tai Chi+tDCS group were significantly higher than walking+tDCS group(P=0.011)and walking+sham tDCS group(P=0.002).Partial correlation analysis showed that the change of MoCA score was correlated with the change of Fz amplitude(r=0.261,P=0.034).Conclusion:A 12-week intervention of Tai Chi combined with tDCS can improve the cognitive function and increase Pz amplitude,Fz amplitude,Cz amplitude in MCI patients,and the change of overall cognitive func-tion may be related to the change of Fz amplitude.
mild cognitive impairmentTai Chitranscranial direct current stimulationevent-related potentialP300
万方数据
维普
