Objective To understand the changing resistance rate of Serratia isolates collected across China to commonly used antibiotics.Methods The participating member hospitals of China Antimicrobial Surveillance Network(CHINET)used disk diffusion method or automated susceptibility testing system to conduct antimicrobial susceptibility testing of Serratia isolates according to the unified technical protocol.Results A total of 17 226 strains of Serratia were collected from 53 hospitals across China from January 2015 to December 2021.The number of Serratia isolates increased from 959 in 2015 to 3 588 in 2021.Overall,about 7.3％(1 265/17 226)of the strains were isolated from outpatients and emergency patients and 92.7％(15 961/17 226)of the strains were isolated from inpatients.About half of the strains(57.5％±2.5％)were isolated from respiratory samples,followed by blood samples(11.5％±1.5％).Over the 7-year period,the resistance rates of Serratia isolates to the antimicrobial agents tested decreased to some extent except ampicillin,cefazolin and nitrofurantoin.The resistance rates to imipenem and meropenem decreased from 8.1％and 8.3％to 5.3％and 5.2％,respectively.The strains isolated from adults in tertiary hospitals showed higher resistance rates to cefoperazone-sulbactam,ceftazidime-avibactam,cefotaxime,imipenem,nitrofurantoin and tigecycline compared to the strains isolated from secondary hospitals.The strains isolated from tertiary hospitals showed lower resistance rates to other antibacterial agents than the strains isolated from secondary hospitals.The Serratia isolates from children showed resistance rates lower than 5％to cefoperazone-sulbactam,piperacillin-tazobactam,amikacin,trimethoprim-sulfamethoxazole and tigecycline.The Serratia isolates from ICUs generally had higher resistance rates than the isolates from other clinical settings.The overall prevalence of carbapenem-resistant Enterobacterales(CRE)was 8.2％in the 7-year period.Conclusions The Serratia isolates showed slightly decreasing resistance rates to most of the antimicrobial agents tested over the 7-year period from 2015 to 2021.It is particularly important to strengthen antimicrobial resistance surveillance and rational use of antibiotics in order to reduce the resistance rates.Proper implementation of hospital infection control measures can effectively reduce the emergence of drug-resistant bacteria.
维普
万方数据