2010-2021年上海市某三甲中医医院尿液临床分离菌的分布和耐药性分析
Distribution and drug resistance of the bacterial strains isolated from urine in a tertiary Traditional Chinese Medicine hospital in Shanghai from 2010 to 2021
裴凌燕 1谢国艳 1王江丽 1梁斌 1冯琪 1刘庆中1
作者信息
- 1. 上海中医药大学附属市中医医院检验科,上海 200071
- 折叠
摘要
目的 了解上海市某三甲中医医院12年间尿液标本临床分离菌的分布及其耐药特点,为临床经验性用药提供依据.方法 回顾性分析2010年1月一2021年12月尿路感染患者资料及其尿液标本临床分离菌的种类和耐药性.结果 本组资料共收集非重复临床分离菌5 231株,其中大肠埃希菌占52.8％,肠球菌属占19.1％,克雷伯菌属占11.1％.各年龄段患者尿液分离菌以60～89岁老年人最多见(76.0％),44岁以下的年轻人最少(3.1％);细菌多数分离自女性患者(75.8％),但铜绿假单胞菌和鲍曼不动杆菌男性多于女性(55.3％对44.7％和67.7％对32.3％).肾病科分离的菌株数较其他科室多见(占13.7％),其中大肠埃希菌在重症监护病房(ICU)的分布最低,而肠球菌属在ICU分布最高.肠杆菌目细菌对碳青霉烯类、头霉素类、阿米卡星、头孢吡肟、β内酰胺酶抑制剂复方制剂耐药率低,具有较高的敏感率;铜绿假单胞菌对碳青霉烯类、氨基糖苷类、β内酰胺酶抑制剂复方制剂的耐药率低,其敏感率均高于鲍曼不动杆菌(≥54.6％对≤39.8％).革兰阳性球菌对糖肽类抗菌药物耐药率低,未发现万古霉素耐药的金黄色葡萄球菌和粪肠球菌,屎肠球菌对万古霉素的耐药率为2.7％.主要临床分离耐药菌株在60～89岁的老年患者中分布最高;ICU和急诊科分离出较多的耐药菌株.结论 该中医医院相比综合性医院的特点是老年患者占比很高,在治疗尿路感染患者时需更加谨慎.尿液标本临床分离菌以大肠埃希菌、肠球菌属和肺炎克雷伯菌为主;经验性用药治疗应结合患者年龄、性别以及病原菌种类的分布特点进行综合考量,积极送检尿培养及药敏试验,根据药敏试验结果合理选用抗菌药物,并加强耐药性监测.
Abstract
Objective To investigate the distribution and antibiotic resistance profiles of the bacterial strains isolated from urine samples in a tertiary Traditional Chinese Medicine hospital in Shanghai in the 12-year period from 2010 through 2021 for better empirical antibiotic use in clinical practice.Methods The clinical data of patients with urinary tract infection,including the species and antibiotic resistance of the bacterial strains isolated from urine samples from January 2010 to December 2021 were retrospectively analyzed.Results A total of 5 231 nondupliate bacterial strains were isolated,among which E.coli was the most common(52.8％),followed by Enterococcus spp(19.1％)and Klebsiella spp(11.1％).Most of the urinary isolates(76.0％)were isolated from the elderly aged 60-89,and only 3.1％of the strains were isolated from the young people aged under 44.Most of the bacterial strains were isolated from female patients(75.8％),however,more P.aeruginosa and A.baumannii were isolated from male patients compared to female patients(55.3％vs 44.7％and 67.7％vs 32.3％).About 13.7％of the strains were collected from the Department of Nephrology,more than the strains from any other clincial department.In intensive care unit(ICU),the proportion of E.coli was the lowest,while the proportion of Enterococcus spp was the highest.Enterobacterales showed lower resistance raets to carbapenems,cephamycin,amikacin,cefepime,and β-lactam/β-lactamase inhibitor combinations.P.aeruginosa showed higher susceptibility rates to carbapenems,aminoglycosides and β-lactam/β-lactamase inhibitor combinations compared to A.baumannii(≥54.6％vs≤39.8％).Gram-positive cocci were highly sensitive to glycopeptide antibiotics.No SS.aureus or E.faecalis isolates were found resistant to vancomycin.About 2.7％of the E.faecium isolates were resistant to vancomycin.The prevalence of drug-resistant bacteria was the highest in elderly patients,and in the strains isolated from ICU and emergency department.Conclusions Compared with general hospitals,a high proportion of elderly patients were treated in this hospital.It should be more cautious in the treatment of patients with urinary tract infection.The major bacterial species isolated from urine were E.coli,Enterococcus,and K.pneumoniae.Empirical treatment should be prescribed considering patient age and gender as well as the species and distribution of pathogenic bacteria.Urine culture and antibiotic susceptibility testing should be performed proactively.Appropriate antimicrobial agents should be selected according to the results of antimicrobial susceptibility testing.Antimicrobial ressitance surveillance should also be strengthened.
关键词
尿液标本/抗菌药物/细菌分布/细菌耐药性Key words
urine specimen/antimicrobial agent/distribution/antimicrobial resistance surveillance引用本文复制引用
出版年
2024
NETL
NSTL
万方数据