PURPOSE:To investigate the effect of preemptive analgesia on postoperative pain relief after minimally inva-sive extraction of impacted teeth and the modified Dental Anxiety Scale(MDAS)score.METHODS:A total of 100 pa-tients with impacted teeth admitted to Rudong Hospital of Traditional Chinese Medicine in Nantong City from July 2021 to May 2022 were selected and randomly divided into the experimental group(minimally invasive tooth extraction combined with preemptive pain relief treatment,n=50)and control group(minimally invasive tooth extraction,n=50)using a random number table method.The operation time,intraoperative blood pressure and heart rate,analgesic efficacy,postoperative vi-sual analogue scale(VAS score)of pain,postoperative MDAS score and adverse reactions were compared between the two groups,and the data were statistically analyzed by SPSS 22.0 software package.RESULTS:The operation time of the ex-perimental group was significantly less than that of the control group(P<0.05).VAS scores at 5 h,10 h and 24 h in the exper-imental group were significantly lower than those in the control group(P<0.05).The MDAS score after treatment was lower than before treatment,and the experimental group was significantly lower than the control group(P<0.05).The incidence of adverse reactions after treatment was lower in both groups,and there was no significant difference between the two groups(P>0.05).CONCLUSIONS:Preemptive analgesia has a good analgesic effect on minimally invasive extraction of impacted teeth,which can improve the anxiety of patients,and has fewer adverse reactions.It can be widely used in clinical practice.