Oral squamous cell carcinoma(OSCC)is the sixth most common malignant tumor in the world.The occurrence and development of oral cancer are closely related to tumor microenvironment(TME).Cancer-associated fibroblast(CAF)participated in epithelial-mesenchymal transition,remodel extracellular matrix,and activate various biological pathways by secreting various growth factors,cytokines,inflammatory factors,and exosomes,which are of great significance to the oc-currence,development,and treatment of OSCC.This article reviews the origin,characteristics,heterogeneity of CAF,and the impact of CAF on the biological behavior of OSCC.
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