口腔种植体周围菌群对种植体周围炎影响的meta分析
A PRISMA meta-analysis regarding the impact of surrounding bacteria of oral implant on periimplantitis
古丽斯旦·麦吾拉江 1李晨曦 2龚忠诚 1热依拉·居热提 3姬晓炜4
作者信息
- 1. 新疆医科大学第一附属医院(附属口腔医院)口腔颌面肿瘤外科,新疆维吾尔自治区口腔医学研究所,新疆 乌鲁木齐 830054
- 2. 新疆医科大学第一附属医院(附属口腔医院)口腔颌面肿瘤外科,新疆维吾尔自治区口腔医学研究所,新疆 乌鲁木齐 830054;华中科技大学同济医学院附属协和医院 口腔医学中心,口腔颌面发育与再生湖北省重点实验室,湖北 武汉 430022
- 3. 新疆医科大学第一附属医院(附属口腔医院)牙周病科,新疆 乌鲁木齐 830054
- 4. 新疆医科大学第一附属医院(附属口腔医院)口腔修复种植科,新疆 乌鲁木齐 830054
- 折叠
摘要
目的:系统评价细菌微生物与口腔种植体周围炎(periimplantitis,PI)发生的相关性.方法:计算机检索Web of Science、PubMed、Scopus、Embase、CNKI 和 The Cochrane Library 数据库,检索时限从建库至 2023年12月,汇集 PI 受试者种植体周围菌群分布的临床研究.运用Stata 14.2和R 4.0.4软件,通过随机效应模型进行荟萃分析.使用改良纽卡斯尔-渥太华量表(the Newcastle-Ottawa Scale,NOS)及乔安娜·布里格斯研究所(Joanna Briggs Institute,JBI)报告检查表进行偏倚风险评价.结果:共纳入13项研究,1274例参与者(1 688个种植体).Meta分析结果表明,PI与表皮葡萄球菌、牙龈卟啉单胞菌、福赛斯坦纳菌、齿垢密螺旋体、具核梭杆菌和中间普氏菌暴露有关(P均＜0.05).细菌计数作为结果和亚组分析的结果大多无有效结论.结论:PI与表皮葡萄球菌及特定牙周病原体(牙龈卟啉单胞菌、福赛斯坦纳菌、齿垢密螺旋体、具核梭杆菌和中间普氏菌)相关,但仍需继续完善多中心前瞻性队列研究以证实目前结论.
Abstract
PURPOSE:To systematically evaluate the correlation between bacterial microorganisms and periimplantitis pathogenesis.METHODS:Web of Science,PubMed,Scopus,Embase,CNKI,and The Cochrane Library were electroni-cally retrieved to collect clinical studies related to bacterial distribution in subjects with periimplantitis from outset to De-cember 2023.Meta analysis was performed using random-effect model by Stata 14.2 and R 4.0.4 software.Modified New-castle-Ottawa Scale(NOS)and Joanna Briggs Institute(JBI)checklist were used to perform the risk of bias assessment.RESULTS:A total of thirteen studies,containing 1 274 participants(1 688 dental implants)were included.Compared with non-periimplantitis,periimplantitis was associated with the exposure of Staphylococcus epidermidis(S.e),Porphyromonas gingivalis(P.g),Tannerella forsythia(T.f),Treponema denticola(T.d),Fusobacterium nucleatum(F.n),and Prevotella inter-media(P.i)(P＜0.05).Results of data synthesis for bacterial count as outcome and for subgroup analyses were mostly incon-clusive.CONCLUSIONS:Periimplantitis is associated with the presence of S.e and specific periodontopathogens(P.g,T.f,T.d,F.n and P.i).However,multicentric prospective cohort studies are needed to confirm the present findings.
关键词
种植体周围炎/细菌/微生物群/风险因素/临床预后Key words
Periimplantitis/Bacteria/Microbiota/Risk factors/Clinical prognosis引用本文复制引用
基金项目
国家自然科学基金(82360481)
口腔颌面发育与再生湖北省重点实验室开放课题基金(2022kqhm008)
新疆维吾尔自治区科研创新项目(XJ2023G174)
天山英才医药卫生领军人才(TSYC202301A001)
出版年
2024
NETL
NSTL
万方数据