Preparation,characterization and drug release of electrospun MNZ/PLGA nanofiber membranes
Objective Periodontitis is a chronic infectious disease affecting the periodontal tissues,mainly caused by bacteria in dental plaque,through the effective continuous release of drugs,to achieve the purpose of killing bacteria and effectively treating periodontitis.Methods In this study,electrospinning technology was used to stretch organic polymers into nanofibers under high electric field,and nanofiber membrane was formed on the collection drum.Different contents of metronidazole(MNZ)(1wt％,3wt％,5wt％)were loaded onto the nanofiber film of poly(lactic acid-co-glycolic acid)(PLGA).The MNZ/PLGA nanofiber films were characterized by scanning electron microscopy,Fourier transform infrared spectroscopy,thermogravimetric analysis,hydrophilicity test,tensile test,biocompatibility and drug release.Results With the increase of metronidazole content,the diameter of PLGA composite nanofibers gradually increased,and the 3wt％MNZ/PLGA composite membrane was uniform.When the content of metronidazole reached 5wt％,the fiber fibers adhered seriously,and large granular droplets were agglomerated.MNZ appears to be embedded and adsorbed on PLGA,and all groups exhibit good physicochemical properties.The nanofiber membrane gradually changed from hydrophobic to hydrophilic,and the tensile property decreased gradually with the increase of metronidazole content,and it had good thermal stability.Conclusion In drug release,the sustained release effect of 3wt％MNZ/PLGA membrane was better than other groups.The 3wt％MNZ/PLGA membrane has good biocompatibility,porous structure and high specific surface area,which is conducive to cell adsorption,superior mechanical properties,and stable and durable sustained release effect.The preparation of MNZ/PLGA biofilm provides some theoretical support for the optimal treatment of periodontitis.
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