Inhibition of bacterial carbonic anhydrase as a new strategy to combat bacterial drug resistance
Bacterial multi-resistance and cross-resistance to antibiotics urgently need to be controlled in combination with other effective targeted alternative strategies.Carbonic anhydrase(CAs)is a metalloenzyme superfamily that catalyzes the reversible reaction of CO2 hydrating to HCO3 and H+,and its activity affects bacterial proliferation,biosynthesis and persistent infection of pathogens in the host.Targeted inhibition of CAs activity may reduce bacterial survival and adaptation,but it does not produce the same antibiotic resistance as conventional antibiotics.Bacterial CAs hold promise as targets for the development of novel antibacterial drugs that are not yet clinically resistant.The paper provided reviews of the classifications and structures of bacterial CAs,their physiological functions,and the progress of research on existing CA inhibitors in bacteria,which can provide a reference for the development of new antibacterial drugs and solve clinical drug resistance problems.
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