The combination of β-lactamase inhibitors with broad-spectrum β-lactam antibiotics is one of the effective strategies to meet the challenge of bacterial resistance.Currently,β-lactamase inhibitors mainly used on the market include oxapenems(clavulanic acid),penicillane sulfones(sulbactam and tazobactam)and diazabicyclooctanes(avibactam),according to their chemical structure.In this paper,the stability and degradation mechanisms/characteristics of the β-lactamase inhibitors were reviewed.Combined with the methods of related substance determination in the specifications of pharmacopeia,the strategy for the impurity profiling control of the β-lactamase inhibitors was discussed.
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