Quaternary ammonium antimicrobial agents belong to a class of cationic biocides with a broad spectrum of antimicrobial activity,including benzalkonium chloride,benzododecinium bromide,polyquaternium-1,benzethonium chloride,cetrimide,etc.They are widely used as bacteriostatic agents in pharmaceutical preparations or as disinfectants for drug production and medical environmental control.In this paper,the dosage,application range,bacteriostatic ability,and safety of commonly used quaternary ammonium antimicrobial agents in pharmaceutical preparations were summarized in order to have a more comprehensive understanding of the properties of these bacteriostatic agents and to provide a reference for rational selection of quaternary ammonium bacteriostatic agents in pharmaceutical preparations.
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