Meta-analysis of disease burden in ICU patients infected with multidrug resistant bacteria in China
Objective To understand the disease burden of patients with multidrug resistance bacteria in the ICU in China and to provide a reference for further research on multidrug resistance.Methods Published studies on the disease burden of patients with multidrug resistance bacteria in the ICU in China were collected from the Chinese databases,which contained CNKI,Wanfang,VIP and SinoMed,and the English databases,which covered PubMed,Embase,Web of Science and The Cochrane Library,in October 2022.Two reviewers independently screened literature and extracted data.Then Meta-analysis was performed using Review Manager 5.4 software.Results A total of 18 works of Chinese and English literature were included.The risk of death in ICU patients in China with multidrug resistance bacterial infections was 1.54～3.00 times that in patients without multidrug resistance bacterial infections,and the average length of stay in patients with multidrug resistance bacterial infections was 4.11～20.17 days longer than that in patients without multidrug resistance bacterial infections.Studies on hospitalization costs had shown that ICU patients in China with multidrug resistance bacterial infections would increase hospitalization costs.Conclusion Multidrug resistance bacterial infections in ICU patients in China may increase the risk of death and economic burden.However,all of the studies were retrospective studies and single-center studies were mainly conducted,so the results should be treated with caution.
NETL
NSTL
万方数据
